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Glycosylation Improves the Proteolytic Stability of Exenatide.
Chandrashekar C, Nishiuchi Y, White BF, Arsenakis Y, Lin F, McNeill SM, Zhao P, van Dun S, Koijen A, Kajihara Y, Wootten D, van den Bos LJ, Wade JD, Hossain MA. Chandrashekar C, et al. Among authors: zhao p. Bioconjug Chem. 2023 Jun 21;34(6):1014-1018. doi: 10.1021/acs.bioconjchem.3c00120. Epub 2023 May 16. Bioconjug Chem. 2023. PMID: 37192432
Activation of the GLP-1 receptor by a non-peptidic agonist.
Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D. Zhao P, et al. Nature. 2020 Jan;577(7790):432-436. doi: 10.1038/s41586-019-1902-z. Epub 2020 Jan 8. Nature. 2020. PMID: 31915381
Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination.
Liang YL, Zhao P, Draper-Joyce C, Baltos JA, Glukhova A, Truong TT, May LT, Christopoulos A, Wootten D, Sexton PM, Furness SGB. Liang YL, et al. Among authors: zhao p. ACS Pharmacol Transl Sci. 2018 Jul 26;1(1):12-20. doi: 10.1021/acsptsci.8b00017. eCollection 2018 Sep 14. ACS Pharmacol Transl Sci. 2018. PMID: 32219201 Free PMC article.
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D. Zhang X, et al. Among authors: zhao p. Mol Cell. 2020 Nov 5;80(3):485-500.e7. doi: 10.1016/j.molcel.2020.09.020. Epub 2020 Oct 6. Mol Cell. 2020. PMID: 33027691 Free article.
Chemical Synthesis and Characterization of a Nonfibrillating Glycoglucagon.
Liu M, Zhao P, Uddin MH, Li W, Lin F, Chandrashekar C, Nishiuchi Y, Kajihara Y, Forbes BE, Wootten D, Wade JD, Hossain MA. Liu M, et al. Among authors: zhao p. Bioconjug Chem. 2021 Oct 20;32(10):2148-2153. doi: 10.1021/acs.bioconjchem.1c00419. Epub 2021 Sep 8. Bioconjug Chem. 2021. PMID: 34494823
9,027 results