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Clinical roles of soluble PD-1 and PD-L1 in plasma of NSCLC patients treated with immune checkpoint inhibitors.
Himuro H, Nakahara Y, Igarashi Y, Kouro T, Higashijima N, Matsuo N, Murakami S, Wei F, Horaguchi S, Tsuji K, Mano Y, Saito H, Azuma K, Sasada T. Himuro H, et al. Among authors: higashijima n. Cancer Immunol Immunother. 2023 Aug;72(8):2829-2840. doi: 10.1007/s00262-023-03464-w. Epub 2023 May 16. Cancer Immunol Immunother. 2023. PMID: 37188764 Free PMC article.
Circulating IL-6 and not its circulating signaling components sIL-6R and sgp130 demonstrate clinical significance in NSCLC patients treated with immune checkpoint inhibitors.
Nakahara Y, Kouro T, Motoyama S, Miura M, Fujita K, Igarashi Y, Higashijima N, Matsuo N, Himuro H, Wei F, Horaguchi S, Tsuji K, Mano Y, Komahashi M, Saito H, Azuma K, Sasada T. Nakahara Y, et al. Among authors: higashijima n. Front Cell Dev Biol. 2024 Jan 16;11:1324898. doi: 10.3389/fcell.2023.1324898. eCollection 2023. Front Cell Dev Biol. 2024. PMID: 38469154 Free PMC article.
Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells.
Zhong P, Nakata K, Oyama K, Higashijima N, Sagara A, Date S, Luo H, Hayashi M, Kubo A, Wu C, He S, Yamamoto T, Koikawa K, Iwamoto C, Abe T, Ikenaga N, Ohuchida K, Morisaki T, Oda Y, Kuba K, Nakamura M. Zhong P, et al. Among authors: higashijima n. J Exp Clin Cancer Res. 2024 May 8;43(1):138. doi: 10.1186/s13046-024-03060-5. J Exp Clin Cancer Res. 2024. PMID: 38715057 Free PMC article.
MicroRNA-20a in extracellular vesicles derived from duodenal fluid is a possible biomarker for pancreatic ductal adenocarcinoma.
Taniguchi T, Ideno N, Araki T, Miura S, Yamamoto M, Nakafusa T, Higashijima N, Yamamoto T, Tamura K, Nakamura S, Abe T, Ikenaga N, Nakata K, Ohuchida K, Oda Y, Ohtsuka T, Nakamura M. Taniguchi T, et al. Among authors: higashijima n. DEN Open. 2024 Mar 2;4(1):e333. doi: 10.1002/deo2.333. eCollection 2024 Apr. DEN Open. 2024. PMID: 38434144 Free PMC article.
BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice.
Hayakawa Y, Tsuboi M, Asfaha S, Kinoshita H, Niikura R, Konishi M, Hata M, Oya Y, Kim W, Middelhoff M, Hikiba Y, Higashijima N, Ihara S, Ushiku T, Fukayama M, Tailor Y, Hirata Y, Guha C, Yan KS, Koike K, Wang TC. Hayakawa Y, et al. Among authors: higashijima n. Gastroenterology. 2019 Mar;156(4):1066-1081.e16. doi: 10.1053/j.gastro.2018.11.024. Epub 2018 Nov 15. Gastroenterology. 2019. PMID: 30448068 Free PMC article.
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