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Covalent Inhibition by a Natural Product-Inspired Latent Electrophile.
Byun DP, Ritchie J, Jung Y, Holewinski R, Kim HR, Tagirasa R, Ivanic J, Weekley CM, Parker MW, Andresson T, Yoo E. Byun DP, et al. Among authors: andresson t. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15. J Am Chem Soc. 2023. PMID: 37183434 Free PMC article.
Investigating the NRAS 5' UTR as a target for small molecules.
Balaratnam S, Torrey ZR, Calabrese DR, Banco MT, Yazdani K, Liang X, Fullenkamp CR, Seshadri S, Holewinski RJ, Andresson T, Ferré-D'Amaré AR, Incarnato D, Schneekloth JS Jr. Balaratnam S, et al. Among authors: andresson t. Cell Chem Biol. 2023 Jun 15;30(6):643-657.e8. doi: 10.1016/j.chembiol.2023.05.004. Epub 2023 May 30. Cell Chem Biol. 2023. PMID: 37257453
Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition.
Park JE, Kirsch K, Lee H, Oliva P, Ahn JI, Ravishankar H, Zeng Y, Fox SD, Kirby SA, Badhwar P, Andresson T, Jacobson KA, Lee KS. Park JE, et al. Among authors: andresson t. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2305037120. doi: 10.1073/pnas.2305037120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603740 Free PMC article.
A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma.
Ligon JA, Sundby RT, Wedekind MF, Arnaldez FI, Del Rivero J, Wiener L, Srinivasan R, Spencer M, Carbonell A, Lei H, Shern J, Steinberg SM, Figg WD, Peer CJ, Zimmerman S, Moraly J, Xu X, Fox S, Chan K, Barbato MI, Andresson T, Taylor N, Pacak K, Killian JK, Dombi E, Linehan WM, Miettinen M, Piekarz R, Helman LJ, Meltzer P, Widemann B, Glod J. Ligon JA, et al. Among authors: andresson t. Clin Cancer Res. 2023 Jan 17;29(2):341-348. doi: 10.1158/1078-0432.CCR-22-2168. Clin Cancer Res. 2023. PMID: 36302175 Free PMC article. Clinical Trial.
83 results