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Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1.
Amambua-Ngwa A, Button-Simons KA, Li X, Kumar S, Brenneman KV, Ferrari M, Checkley LA, Haile MT, Shoue DA, McDew-White M, Tindall SM, Reyes A, Delgado E, Dalhoff H, Larbalestier JK, Amato R, Pearson RD, Taylor AB, Nosten FH, D'Alessandro U, Kwiatkowski D, Cheeseman IH, Kappe SHI, Avery SV, Conway DJ, Vaughan AM, Ferdig MT, Anderson TJC. Amambua-Ngwa A, et al. Among authors: taylor ab. Nat Microbiol. 2023 Jul;8(7):1213-1226. doi: 10.1038/s41564-023-01377-z. Epub 2023 May 11. Nat Microbiol. 2023. PMID: 37169919 Free PMC article.
Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites.
Valentim CL, Cioli D, Chevalier FD, Cao X, Taylor AB, Holloway SP, Pica-Mattoccia L, Guidi A, Basso A, Tsai IJ, Berriman M, Carvalho-Queiroz C, Almeida M, Aguilar H, Frantz DE, Hart PJ, LoVerde PT, Anderson TJ. Valentim CL, et al. Among authors: taylor ab. Science. 2013 Dec 13;342(6164):1385-9. doi: 10.1126/science.1243106. Epub 2013 Nov 21. Science. 2013. PMID: 24263136 Free PMC article.
Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.
Chevalier FD, Le Clec'h W, McDew-White M, Menon V, Guzman MA, Holloway SP, Cao X, Taylor AB, Kinung'hi S, Gouvras AN, Webster BL, Webster JP, Emery AM, Rollinson D, Garba Djirmay A, Al Mashikhi KM, Al Yafae S, Idris MA, Moné H, Mouahid G, Hart PJ, LoVerde PT, Anderson TJC. Chevalier FD, et al. Among authors: taylor ab. PLoS Pathog. 2019 Oct 25;15(10):e1007881. doi: 10.1371/journal.ppat.1007881. eCollection 2019 Oct. PLoS Pathog. 2019. PMID: 31652296 Free PMC article.
An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.
Guzman MA, Rugel AR, Tarpley RS, Alwan SN, Chevalier FD, Kovalskyy DP, Cao X, Holloway SP, Anderson TJC, Taylor AB, McHardy SF, LoVerde PT. Guzman MA, et al. Among authors: taylor ab. PLoS Negl Trop Dis. 2020 Aug 18;14(8):e0008517. doi: 10.1371/journal.pntd.0008517. eCollection 2020 Aug. PLoS Negl Trop Dis. 2020. PMID: 32810153 Free PMC article.
Rational approach to drug discovery for human schistosomiasis.
LoVerde PT, Alwan SN, Taylor AB, Rhodes J, Chevalier FD, Anderson TJ, McHardy SF. LoVerde PT, et al. Among authors: taylor ab. Int J Parasitol Drugs Drug Resist. 2021 Aug;16:140-147. doi: 10.1016/j.ijpddr.2021.05.002. Epub 2021 Jun 4. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34111649 Free PMC article. Review.
Corrigendum to "Rational approach to drug discovery for human schistosomiasis" [Int. J. Parasitol. Drugs Drug Resist. 16 (2021) 140-147].
LoVerde PT, Alwan SN, Taylor AB, Rhodes J, Chevalier FD, Anderson TJ, McHardy SF. LoVerde PT, et al. Among authors: taylor ab. Int J Parasitol Drugs Drug Resist. 2022 Apr;18:103. doi: 10.1016/j.ijpddr.2022.01.003. Epub 2022 Jan 19. Int J Parasitol Drugs Drug Resist. 2022. PMID: 35067439 Free PMC article. No abstract available.
Schistosome Sulfotransferases: Mode of Action, Expression and Localization.
Guzman MA, Rugel A, Alwan SN, Tarpley R, Taylor AB, Chevalier FD, Wendt GR, Collins JJ 3rd, Anderson TJC, McHardy SF, LoVerde PT. Guzman MA, et al. Among authors: taylor ab. Pharmaceutics. 2022 Jul 6;14(7):1416. doi: 10.3390/pharmaceutics14071416. Pharmaceutics. 2022. PMID: 35890311 Free PMC article.
Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Rugel AR, Guzman MA, Taylor AB, Chevalier FD, Tarpley RS, McHardy SF, Cao X, Holloway SP, Anderson TJC, Hart PJ, LoVerde PT. Rugel AR, et al. Among authors: taylor ab. Int J Parasitol Drugs Drug Resist. 2020 Aug;13:8-15. doi: 10.1016/j.ijpddr.2020.04.001. Epub 2020 Apr 10. Int J Parasitol Drugs Drug Resist. 2020. PMID: 32315953 Free PMC article.
272 results