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Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk.
Kojima S, Koyama S, Ka M, Saito Y, Parrish EH, Endo M, Takata S, Mizukoshi M, Hikino K, Takeda A, Gelinas AF, Heaton SM, Koide R, Kamada AJ, Noguchi M, Hamada M; Biobank Japan Project Consortium; Kamatani Y, Murakawa Y, Ishigaki K, Nakamura Y, Ito K, Terao C, Momozawa Y, Parrish NF. Kojima S, et al. Among authors: nakamura y. Nat Genet. 2023 Jun;55(6):939-951. doi: 10.1038/s41588-023-01390-2. Epub 2023 May 11. Nat Genet. 2023. PMID: 37169872
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression.
Takase S, Hiroyama T, Shirai F, Maemoto Y, Nakata A, Arata M, Matsuoka S, Sonoda T, Niwa H, Sato S, Umehara T, Shirouzu M, Nishigaya Y, Sumiya T, Hashimoto N, Namie R, Usui M, Ohishi T, Ohba SI, Kawada M, Hayashi Y, Harada H, Yamaguchi T, Shinkai Y, Nakamura Y, Yoshida M, Ito A. Takase S, et al. Among authors: nakamura y. Nat Commun. 2023 Jan 12;14(1):23. doi: 10.1038/s41467-022-35404-0. Nat Commun. 2023. PMID: 36635268 Free PMC article.
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery.
Wuputra K, Tsai MH, Kato K, Ku CC, Pan JB, Yang YH, Saito S, Wu CC, Lin YC, Cheng KH, Kuo KK, Noguchi M, Nakamura Y, Yoshioka T, Wu DC, Lin CS, Yokoyama KK. Wuputra K, et al. Among authors: nakamura y. Inflamm Regen. 2023 Aug 18;43(1):42. doi: 10.1186/s41232-023-00290-6. Inflamm Regen. 2023. PMID: 37596694 Free PMC article.
Chemically defined cytokine-free expansion of human haematopoietic stem cells.
Sakurai M, Ishitsuka K, Ito R, Wilkinson AC, Kimura T, Mizutani E, Nishikii H, Sudo K, Becker HJ, Takemoto H, Sano T, Kataoka K, Takahashi S, Nakamura Y, Kent DG, Iwama A, Chiba S, Okamoto S, Nakauchi H, Yamazaki S. Sakurai M, et al. Among authors: nakamura y. Nature. 2023 Mar;615(7950):127-133. doi: 10.1038/s41586-023-05739-9. Epub 2023 Feb 22. Nature. 2023. PMID: 36813966 Free article.
Deficiency of ribosomal protein S26, which is mutated in a subset of patients with Diamond Blackfan anemia, impairs erythroid differentiation.
Piantanida N, La Vecchia M, Sculco M, Talmon M, Palattella G, Kurita R, Nakamura Y, Ronchi AE, Dianzani I, Ellis SR, Fresu LG, Aspesi A. Piantanida N, et al. Among authors: nakamura y. Front Genet. 2022 Dec 12;13:1045236. doi: 10.3389/fgene.2022.1045236. eCollection 2022. Front Genet. 2022. PMID: 36579335 Free PMC article.
Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia.
Lu D, Xu Z, Peng Z, Yang Y, Song B, Xiong Z, Ma Z, Guan H, Chen B, Nakamura Y, Zeng J, Liu N, Sun X, Chen D. Lu D, et al. Among authors: nakamura y. Front Genet. 2022 May 17;13:881937. doi: 10.3389/fgene.2022.881937. eCollection 2022. Front Genet. 2022. PMID: 35656314 Free PMC article.
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