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Long-term effects of canagliflozin treatment on the skeleton of aged UM-HET3 mice.
Yildirim G, Bergamo ETP, Poudel SB, Ruff RR, Dixit M, Hu B, Mijares DQ, Witek L, Chlebek C, Harrison DE, Strong R, Miller RA, Ladiges W, Bromage TG, Rosen CJ, Yakar S. Yildirim G, et al. Among authors: strong r. Geroscience. 2023 Jun;45(3):1933-1951. doi: 10.1007/s11357-023-00803-8. Epub 2023 May 11. Geroscience. 2023. PMID: 37166526 Free PMC article.
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.
Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Harrison DE, et al. Among authors: strong r. Geroscience. 2024 Feb;46(1):795-816. doi: 10.1007/s11357-023-01011-0. Epub 2023 Dec 2. Geroscience. 2024. PMID: 38041783 Free PMC article.
Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin.
Miller RA, Harrison DE, Cortopassi GA, Dehghan I, Fernandez E, Garratt M, Geisler JG, Ginsburg BC, Han ML, Kaczorowski CC, Kumar N, Leiser SF, Lopez-Cruzan M, Milne G, Mitchell JR, Nelson JF, Reifsnyder PC, Salmon AB, Korstanje R, Rosenthal N, Strong R. Miller RA, et al. Among authors: strong r. Geroscience. 2024 May 16. doi: 10.1007/s11357-024-01176-2. Online ahead of print. Geroscience. 2024. PMID: 38753230
Response to Chen et al and the Accompanying Commentary.
Sharif A, McGiffin D, Strong R, Trey T, Matas D, Lavee J, Hughes S, Rogers W. Sharif A, et al. Among authors: strong r. Transplantation. 2024 Jun 1;108(6):e81-e82. doi: 10.1097/TP.0000000000005005. Epub 2024 May 24. Transplantation. 2024. PMID: 38809430 No abstract available.
The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride.
Jiang N, Gelfond J, Liu Q, Strong R, Nelson JF. Jiang N, et al. Among authors: strong r. Geroscience. 2024 Apr 17. doi: 10.1007/s11357-024-01161-9. Online ahead of print. Geroscience. 2024. PMID: 38630424
619 results