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An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types.
Chen JK, Merrick KA, Kong YW, Izrael-Tomasevic A, Eng G, Handly ED, Patterson JC, Cannell IG, Suarez-Lopez L, Hosios AM, Dinh A, Kirkpatrick DS, Yu K, Rose CM, Hernandez JM, Hwangbo H, Palmer AC, Vander Heiden MG, Yilmaz ÖH, Yaffe MB. Chen JK, et al. Among authors: yilmaz oh. bioRxiv [Preprint]. 2023 Apr 29:2023.04.28.538590. doi: 10.1101/2023.04.28.538590. bioRxiv. 2023. PMID: 37162991 Free PMC article. Preprint.
PKM2 is not required for colon cancer initiated by APC loss.
Lau AN, Israelsen WJ, Roper J, Sinnamon MJ, Georgeon L, Dayton TL, Hillis AL, Yilmaz OH, Di Vizio D, Hung KE, Vander Heiden MG. Lau AN, et al. Among authors: yilmaz oh. Cancer Metab. 2017 Nov 30;5:10. doi: 10.1186/s40170-017-0172-1. eCollection 2017. Cancer Metab. 2017. PMID: 29214019 Free PMC article.
CRAD as a cytoskeletal tumour suppressor.
Eng G, Braverman J, Yilmaz ÖH. Eng G, et al. Among authors: yilmaz oh. Nat Cell Biol. 2018 Nov;20(11):1232-1233. doi: 10.1038/s41556-018-0225-x. Nat Cell Biol. 2018. PMID: 30361696 No abstract available.
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.
Lau AN, Li Z, Danai LV, Westermark AM, Darnell AM, Ferreira R, Gocheva V, Sivanand S, Lien EC, Sapp KM, Mayers JR, Biffi G, Chin CR, Davidson SM, Tuveson DA, Jacks T, Matheson NJ, Yilmaz O, Vander Heiden MG. Lau AN, et al. Elife. 2020 Jul 10;9:e56782. doi: 10.7554/eLife.56782. Elife. 2020. PMID: 32648540 Free PMC article.
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints.
Kong YW, Dreaden EC, Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz ÖH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB. Kong YW, et al. Among authors: yilmaz oh. Nat Commun. 2020 Aug 17;11(1):4124. doi: 10.1038/s41467-020-17958-z. Nat Commun. 2020. PMID: 32807787 Free PMC article.
Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer.
Schmidt DR, Gramatikov IMT, Sheen A, Williams CL, Hurwitz M, Dodge LE, Holupka E, Kiger WS 3rd, Cornwall-Brady MR, Huang W, Mak HH, Cormier KS, Condon C, Dane Wittrup K, Yilmaz ÖH, Stevenson MA, Down JD, Floyd SR, Roper J, Vander Heiden MG. Schmidt DR, et al. Among authors: yilmaz oh. Commun Med (Lond). 2023 Aug 9;3(1):108. doi: 10.1038/s43856-023-00336-3. Commun Med (Lond). 2023. PMID: 37558833 Free PMC article.
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival.
Tzouanas CN, Sherman MS, Shay JES, Rubin AJ, Mead BE, Dao TT, Butzlaff T, Mana MD, Kolb KE, Walesky C, Pepe-Mooney BJ, Smith CJ, Prakadan SM, Ramseier ML, Tong EY, Joung J, Chi F, McMahon-Skates T, Winston CL, Jeong WJ, Aney KJ, Chen E, Nissim S, Zhang F, Deshpande V, Lauer GM, Yilmaz ÖH, Goessling W, Shalek AK. Tzouanas CN, et al. Among authors: yilmaz oh. bioRxiv [Preprint]. 2023 Dec 1:2023.11.30.569407. doi: 10.1101/2023.11.30.569407. bioRxiv. 2023. PMID: 38077056 Free PMC article. Preprint.
SOX17 enables immune evasion of early colorectal adenomas and cancers.
Goto N, Westcott PMK, Goto S, Imada S, Taylor MS, Eng G, Braverman J, Deshpande V, Jacks T, Agudo J, Yilmaz ÖH. Goto N, et al. Among authors: yilmaz oh. Nature. 2024 Mar;627(8004):636-645. doi: 10.1038/s41586-024-07135-3. Epub 2024 Feb 28. Nature. 2024. PMID: 38418875
158 results