Urrutia R - Search Results

1

Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells.

Fraunhoffer NA, Moreno Vega AI, Abuelafia AM, Morvan M, Lebarbier E, Mary-Huard T, Zimmermann MT, Lomberk G, Urrutia R, Dusetti N, Blum Y, Nicolle R, Iovanna J. Fraunhoffer NA, et al. Among authors: urrutia r. EBioMedicine. 2023 Jun;92:104602. doi: 10.1016/j.ebiom.2023.104602. Epub 2023 May 4. EBioMedicine. 2023. PMID: 37148583 Free PMC article.

2

Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Esparza GV, Leverence EN, De Assuncao TM, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT. Ratnasinghe BD, et al. Among authors: urrutia r. bioRxiv [Preprint]. 2023 Apr 28:2023.04.28.536249. doi: 10.1101/2023.04.28.536249. bioRxiv. 2023. PMID: 37207265 Free PMC article. Updated. Preprint.

3

Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry.

Pollin G, De Assuncao TM, Doria Jorge S, Chi YI, Charlesworth MC, Madden B, Iovanna J, Zimmermann MT, Urrutia R, Lomberk G. Pollin G, et al. Among authors: urrutia r. Biosci Rep. 2023 Oct 31;43(10):BSR20231093. doi: 10.1042/BSR20231093. Biosci Rep. 2023. PMID: 37782747 Free PMC article.

4

A Multi-Layered Computational Structural Genomics Approach Enhances Domain-Specific Interpretation of Kleefstra Syndrome Variants in EHMT1.

Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Chi YI, et al. Among authors: urrutia r. bioRxiv [Preprint]. 2023 Sep 7:2023.09.06.556558. doi: 10.1101/2023.09.06.556558. bioRxiv. 2023. PMID: 37786696 Free PMC article. Updated. Preprint.

5

Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape.

Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT. Ratnasinghe BD, et al. Among authors: urrutia r. Comput Struct Biotechnol J. 2023 Oct 5;21:4790-4803. doi: 10.1016/j.csbj.2023.10.003. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 37841325 Free PMC article.

6

RAG genomic variation causes autoimmune diseases through specific structure-based mechanisms of enzyme dysregulation.

Haque N, Kawai T, Ratnasinghe BD, Wagenknecht JB, Urrutia R, Notarangelo LD, Zimmermann MT. Haque N, et al. Among authors: urrutia r. iScience. 2023 Sep 27;26(10):108040. doi: 10.1016/j.isci.2023.108040. eCollection 2023 Oct 20. iScience. 2023. PMID: 37854700 Free PMC article.

7

A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1.

Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Chi YI, et al. Among authors: urrutia r. Comput Struct Biotechnol J. 2023 Oct 13;21:5249-5258. doi: 10.1016/j.csbj.2023.10.022. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 37954151 Free PMC article.

8

Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction.

Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Jorge SD, et al. Among authors: urrutia r. Front Genet. 2023 Nov 28;14:1291307. doi: 10.3389/fgene.2023.1291307. eCollection 2023. Front Genet. 2023. PMID: 38090150 Free PMC article.

9

Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras^G12D-driven tumors.

Santofimia-Castaño P, Fraunhoffer N, Liu X, Bessone IF, di Magliano MP, Audebert S, Camoin L, Estaras M, Brenière M, Modesti M, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J. Santofimia-Castaño P, et al. Among authors: urrutia r. EMBO Mol Med. 2024 Mar;16(3):475-505. doi: 10.1038/s44321-024-00032-2. Epub 2024 Feb 15. EMBO Mol Med. 2024. PMID: 38360999 Free PMC article.

10

Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression.

Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC. Bursch KL, et al. Among authors: urrutia ra. J Biol Chem. 2024 Apr;300(4):107146. doi: 10.1016/j.jbc.2024.107146. Epub 2024 Mar 7. J Biol Chem. 2024. PMID: 38460939 Free PMC article.

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