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Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension.
Logantha SJRJ, Yamanushi TT, Absi M, Temple IP, Kabuto H, Hirakawa E, Quigley G, Zhang X, Gurney AM, Hart G, Zhang H, Dobrzynski H, Boyett MR, Yanni J. Logantha SJRJ, et al. Among authors: zhang x, zhang h. Philos Trans R Soc Lond B Biol Sci. 2023 Jun 19;378(1879):20220178. doi: 10.1098/rstb.2022.0178. Epub 2023 May 1. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 37122221 Free PMC article.
TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging.
Hao X, Zhang Y, Zhang X, Nirmalan M, Davies L, Konstantinou D, Yin F, Dobrzynski H, Wang X, Grace A, Zhang H, Boyett M, Huang CL, Lei M. Hao X, et al. Among authors: zhang x, zhang h, zhang y. Circ Arrhythm Electrophysiol. 2011 Jun;4(3):397-406. doi: 10.1161/CIRCEP.110.960807. Epub 2011 Apr 14. Circ Arrhythm Electrophysiol. 2011. PMID: 21493874
Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome.
Wu J, Zhang Y, Zhang X, Cheng L, Lammers WJ, Grace AA, Fraser JA, Zhang H, Huang CL, Lei M. Wu J, et al. Among authors: zhang x, zhang h, zhang y. Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1510-23. doi: 10.1152/ajpheart.00357.2011. Epub 2012 Jan 27. Am J Physiol Heart Circ Physiol. 2012. PMID: 22287583 Free PMC article.
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