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Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway.
Ikeda Z, Kamei T, Sasaki Y, Reynolds M, Sakai N, Yoshikawa M, Tawada M, Morishita N, Dougan DR, Chen CH, Levin I, Zou H, Kuno M, Arimura N, Kikukawa Y, Kondo M, Tohyama K, Sato K. Ikeda Z, et al. Among authors: kuno m. J Med Chem. 2023 May 11;66(9):6354-6371. doi: 10.1021/acs.jmedchem.3c00348. Epub 2023 Apr 25. J Med Chem. 2023. PMID: 37120845 Free PMC article.
Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
Yoshikawa M, Saitoh M, Katoh T, Seki T, Bigi SV, Shimizu Y, Ishii T, Okai T, Kuno M, Hattori H, Watanabe E, Saikatendu KS, Zou H, Nakakariya M, Tatamiya T, Nakada Y, Yogo T. Yoshikawa M, et al. Among authors: kuno m. J Med Chem. 2018 Mar 22;61(6):2384-2409. doi: 10.1021/acs.jmedchem.7b01647. Epub 2018 Mar 6. J Med Chem. 2018. PMID: 29485864
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors - Part 3.
Yukawa T, Nakada Y, Sakauchi N, Kamei T, Yamada M, Ohba Y, Fujimori I, Ueno H, Takiguchi M, Kuno M, Kamo I, Nakagawa H, Fujioka Y, Igari T, Ishichi Y, Tsukamoto T. Yukawa T, et al. Among authors: kuno m. Bioorg Med Chem. 2016 Aug 15;24(16):3716-26. doi: 10.1016/j.bmc.2016.06.014. Epub 2016 Jun 8. Bioorg Med Chem. 2016. PMID: 27325446
Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor.
Fujimori I, Yukawa T, Kamei T, Nakada Y, Sakauchi N, Yamada M, Ohba Y, Takiguchi M, Kuno M, Kamo I, Nakagawa H, Hamada T, Igari T, Okuda T, Yamamoto S, Tsukamoto T, Ishichi Y, Ueno H. Fujimori I, et al. Among authors: kuno m. Bioorg Med Chem. 2015 Aug 1;23(15):5000-5014. doi: 10.1016/j.bmc.2015.05.017. Epub 2015 May 15. Bioorg Med Chem. 2015. PMID: 26051602
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors-Part 2.
Yukawa T, Fujimori I, Kamei T, Nakada Y, Sakauchi N, Yamada M, Ohba Y, Ueno H, Takiguchi M, Kuno M, Kamo I, Nakagawa H, Fujioka Y, Igari T, Ishichi Y, Tsukamoto T. Yukawa T, et al. Among authors: kuno m. Bioorg Med Chem. 2016 Jul 15;24(14):3207-17. doi: 10.1016/j.bmc.2016.05.038. Epub 2016 May 21. Bioorg Med Chem. 2016. PMID: 27255177
Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors.
Yogo T, Nagamiya H, Seto M, Sasaki S, Shih-Chung H, Ohba Y, Tokunaga N, Lee GN, Rhim CY, Yoon CH, Cho SY, Skene R, Yamamoto S, Satou Y, Kuno M, Miyazaki T, Nakagawa H, Okabe A, Marui S, Aso K, Yoshida M. Yogo T, et al. Among authors: kuno m. J Med Chem. 2016 Jan 28;59(2):733-49. doi: 10.1021/acs.jmedchem.5b01857. Epub 2016 Jan 8. J Med Chem. 2016. PMID: 26701356
392 results