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A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest.
Li J, Wang H, Zhong Q, Zhu X, Chen SJ, Qian Y, Costakis J, Bunney G, Beiser DG, Leff AR, Lewandowski ED, ÓDonnell JM, Vanden Hoek TL. Li J, et al. Among authors: zhu x. Am J Physiol Heart Circ Physiol. 2015 Jun 1;308(11):H1414-22. doi: 10.1152/ajpheart.00748.2014. Epub 2015 Mar 20. Am J Physiol Heart Circ Physiol. 2015. PMID: 25795713 Free PMC article.
TAT delivery of a PTEN peptide inhibitor has direct cardioprotective effects and improves outcomes in rodent models of cardiac arrest.
Zhu X, Li J, Wang H, Gasior FM, Lee C, Lin S, Zhu Z, Wang Y, Justice CN, O'Donnell JM, Vanden Hoek TL. Zhu X, et al. Among authors: zhu z. Am J Physiol Heart Circ Physiol. 2021 May 1;320(5):H2034-H2043. doi: 10.1152/ajpheart.00513.2020. Epub 2021 Apr 9. Am J Physiol Heart Circ Physiol. 2021. PMID: 33834871 Free PMC article.
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