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Technologies for Direct Detection of Covalent Protein-Drug Adducts.
Pharmaceuticals (Basel). 2023 Apr 5;16(4):547. doi: 10.3390/ph16040547.
Pharmaceuticals (Basel). 2023.
PMID: 37111304
Free PMC article.
Review.
Exploring the Versatility of the Covalent Thiol-Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease.
Mons E, Kim RQ, van Doodewaerd BR, van Veelen PA, Mulder MPC, Ovaa H.
Mons E, et al.
J Am Chem Soc. 2021 May 5;143(17):6423-6433. doi: 10.1021/jacs.0c10513. Epub 2021 Apr 22.
J Am Chem Soc. 2021.
PMID: 33885283
Free PMC article.
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A Comprehensive Guide for Assessing Covalent Inhibition in Enzymatic Assays Illustrated with Kinetic Simulations.
Mons E, Roet S, Kim RQ, Mulder MPC.
Mons E, et al.
Curr Protoc. 2022 Jun;2(6):e419. doi: 10.1002/cpz1.419.
Curr Protoc. 2022.
PMID: 35671150
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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K.
Mons E, Jansen IDC, Loboda J, van Doodewaerd BR, Hermans J, Verdoes M, van Boeckel CAA, van Veelen PA, Turk B, Turk D, Ovaa H.
Mons E, et al.
J Am Chem Soc. 2019 Feb 27;141(8):3507-3514. doi: 10.1021/jacs.8b11027. Epub 2019 Feb 14.
J Am Chem Soc. 2019.
PMID: 30689386
Free PMC article.
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Profiling withanolide A for therapeutic targets in neurodegenerative diseases.
Crane EA, Heydenreuter W, Beck KR, Strajhar P, Vomacka J, Smiesko M, Mons E, Barth L, Neuburger M, Vedani A, Odermatt A, Sieber SA, Gademann K.
Crane EA, et al. Among authors: mons e.
Bioorg Med Chem. 2019 Jun 15;27(12):2508-2520. doi: 10.1016/j.bmc.2019.03.022. Epub 2019 Mar 13.
Bioorg Med Chem. 2019.
PMID: 30929949
Free article.
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Organocatalytic enantioselective Pictet-Spengler reactions for the syntheses of 1-substituted 1,2,3,4-tetrahydroisoquinolines.
Mons E, Wanner MJ, Ingemann S, van Maarseveen JH, Hiemstra H.
Mons E, et al.
J Org Chem. 2014 Aug 15;79(16):7380-90. doi: 10.1021/jo501099h. Epub 2014 Jul 30.
J Org Chem. 2014.
PMID: 25046801
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