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How close are we to targeting the leukemia stem cell?
Pei S, Jordan CT. Pei S, et al. Among authors: jordan ct. Best Pract Res Clin Haematol. 2012 Dec;25(4):415-8. doi: 10.1016/j.beha.2012.10.003. Epub 2012 Oct 23. Best Pract Res Clin Haematol. 2012. PMID: 23200537 Review.
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.
Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, Ashton JM, Pei S, Grose V, O'Dwyer KM, Liesveld JL, Brookes PS, Becker MW, Jordan CT. Lagadinou ED, et al. Among authors: jordan ct. Cell Stem Cell. 2013 Mar 7;12(3):329-41. doi: 10.1016/j.stem.2012.12.013. Epub 2013 Jan 17. Cell Stem Cell. 2013. PMID: 23333149 Free PMC article.
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells.
Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT. Pei S, et al. Among authors: jordan ct. J Biol Chem. 2013 Nov 22;288(47):33542-33558. doi: 10.1074/jbc.M113.511170. Epub 2013 Oct 2. J Biol Chem. 2013. PMID: 24089526 Free PMC article. Clinical Trial.
Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.
Callahan KP, Minhajuddin M, Corbett C, Lagadinou ED, Rossi RM, Grose V, Balys MM, Pan L, Jacob S, Frontier A, Grever MR, Lucas DM, Kinghorn AD, Liesveld JL, Becker MW, Jordan CT. Callahan KP, et al. Among authors: jordan ct. Leukemia. 2014 Oct;28(10):1960-8. doi: 10.1038/leu.2014.93. Epub 2014 Feb 28. Leukemia. 2014. PMID: 24577530 Free PMC article.
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.
Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KL. Zahreddine HA, et al. Among authors: jordan ct. Nature. 2014 Jul 3;511(7507):90-3. doi: 10.1038/nature13283. Epub 2014 May 28. Nature. 2014. PMID: 24870236 Free PMC article.
Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.
Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Alvarez-Calderon F, et al. Among authors: jordan ct. Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29. Clin Cancer Res. 2015. PMID: 25547679 Free PMC article.
Clonality of neutrophilia associated with plasma cell neoplasms: report of a SETBP1 mutation and analysis of a single institution series.
Stevens B, Maxson J, Tyner J, Smith CA, Gutman JA, Robinson W, Jordan CT, Lee CK, Swisshelm K, Tobin J, Wei Q, Schowinsky J, Rinella S, Lee HG, Pollyea DA. Stevens B, et al. Among authors: jordan ct. Leuk Lymphoma. 2016;57(4):927-34. doi: 10.3109/10428194.2015.1094697. Epub 2015 Oct 27. Leuk Lymphoma. 2016. PMID: 26389776 Free PMC article.
MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.
Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM. Riedel SS, et al. Among authors: jordan ct. J Clin Invest. 2016 Apr 1;126(4):1438-50. doi: 10.1172/JCI80825. Epub 2016 Feb 29. J Clin Invest. 2016. PMID: 26927674 Free PMC article.
193 results