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Targeting the β-adrenergic receptor system through G-protein-coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart failure: from bench to bedside.
Rengo G, Perrone-Filardi P, Femminella GD, Liccardo D, Zincarelli C, de Lucia C, Pagano G, Marsico F, Lymperopoulos A, Leosco D. Rengo G, et al. Among authors: lymperopoulos a. Circ Heart Fail. 2012 May 1;5(3):385-91. doi: 10.1161/CIRCHEARTFAILURE.112.966895. Circ Heart Fail. 2012. PMID: 22589366 Review. No abstract available.
alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.
Karkoulias G, Mastrogianni O, Lymperopoulos A, Paris H, Flordellis C. Karkoulias G, et al. Among authors: lymperopoulos a. Cell Signal. 2006 May;18(5):729-39. doi: 10.1016/j.cellsig.2005.06.014. Epub 2005 Aug 10. Cell Signal. 2006. PMID: 16098714
Myocardial β(2) -adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure.
Rengo G, Zincarelli C, Femminella GD, Liccardo D, Pagano G, de Lucia C, Altobelli GG, Cimini V, Ruggiero D, Perrone-Filardi P, Gao E, Ferrara N, Lymperopoulos A, Koch WJ, Leosco D. Rengo G, et al. Among authors: lymperopoulos a. Br J Pharmacol. 2012 Aug;166(8):2348-61. doi: 10.1111/j.1476-5381.2012.01954.x. Br J Pharmacol. 2012. PMID: 22452704 Free PMC article.
Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation.
Drosatos K, Bharadwaj KG, Lymperopoulos A, Ikeda S, Khan R, Hu Y, Agarwal R, Yu S, Jiang H, Steinberg SF, Blaner WS, Koch WJ, Goldberg IJ. Drosatos K, et al. Among authors: lymperopoulos a. Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E489-99. doi: 10.1152/ajpendo.00569.2010. Epub 2010 Dec 7. Am J Physiol Endocrinol Metab. 2011. PMID: 21139071 Free PMC article.
106 results