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Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii.
Introvigne ML, Beardsley TJ, Fernando MC, Leonard DA, Wallar BJ, Rudin SD, Taracila MA, Rather PN, Colquhoun JM, Song S, Fini F, Hujer KM, Hujer AM, Prati F, Powers RA, Bonomo RA, Caselli E. Introvigne ML, et al. Among authors: wallar bj. Antibiotics (Basel). 2023 Mar 24;12(4):644. doi: 10.3390/antibiotics12040644. Antibiotics (Basel). 2023. PMID: 37107006 Free PMC article.
Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.
Powers RA, June CM, Fernando MC, Fish ER, Maurer OL, Baumann RM, Beardsley TJ, Taracila MA, Rudin SD, Hujer KM, Hujer AM, Santi N, Villamil V, Introvigne ML, Prati F, Caselli E, Bonomo RA, Wallar BJ. Powers RA, et al. Among authors: wallar bj. J Med Chem. 2023 Jul 13;66(13):8510-8525. doi: 10.1021/acs.jmedchem.3c00144. Epub 2023 Jun 26. J Med Chem. 2023. PMID: 37358467 Free PMC article.
A comprehensive and contemporary "snapshot" of β-lactamases in carbapenem resistant Acinetobacter baumannii.
Hujer AM, Hujer KM, Leonard DA, Powers RA, Wallar BJ, Mack AR, Taracila MA, Rather PN, Higgins PG, Prati F, Caselli E, Marshall SH, Clarke T, Greco C, Venepally P, Brinkac L, Kreiswirth BN, Fouts DE, Bonomo RA; Antibacterial Resistance Leadership Group (ARLG). Hujer AM, et al. Among authors: wallar bj. Diagn Microbiol Infect Dis. 2021 Feb;99(2):115242. doi: 10.1016/j.diagmicrobio.2020.115242. Epub 2020 Oct 16. Diagn Microbiol Infect Dis. 2021. PMID: 33248392 Free PMC article.
Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.
Curtis BN, Smolen KA, Barlow SJ, Caselli E, Prati F, Taracila MA, Bonomo RA, Wallar BJ, Powers RA. Curtis BN, et al. Among authors: wallar bj. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01183-20. doi: 10.1128/AAC.01183-20. Print 2020 Nov 17. Antimicrob Agents Chemother. 2020. PMID: 32988830 Free PMC article.
1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase.
Caselli E, Fini F, Introvigne ML, Stucchi M, Taracila MA, Fish ER, Smolen KA, Rather PN, Powers RA, Wallar BJ, Bonomo RA, Prati F. Caselli E, et al. Among authors: wallar bj. ACS Infect Dis. 2020 Jul 10;6(7):1965-1975. doi: 10.1021/acsinfecdis.0c00254. Epub 2020 Jun 24. ACS Infect Dis. 2020. PMID: 32502340 Free PMC article.
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