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Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.
J Med Chem. 2023 Jul 13;66(13):8510-8525. doi: 10.1021/acs.jmedchem.3c00144. Epub 2023 Jun 26.
J Med Chem. 2023.
PMID: 37358467
Free PMC article.
Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii.
Introvigne ML, Beardsley TJ, Fernando MC, Leonard DA, Wallar BJ, Rudin SD, Taracila MA, Rather PN, Colquhoun JM, Song S, Fini F, Hujer KM, Hujer AM, Prati F, Powers RA, Bonomo RA, Caselli E.
Introvigne ML, et al.
Antibiotics (Basel). 2023 Mar 24;12(4):644. doi: 10.3390/antibiotics12040644.
Antibiotics (Basel). 2023.
PMID: 37107006
Free PMC article.
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Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses.
Alsenani TA, Rodríguez MM, Ghiglione B, Taracila MA, Mojica MF, Rojas LJ, Hujer AM, Gutkind G, Bethel CR, Rather PN, Introvigne ML, Prati F, Caselli E, Power P, van den Akker F, Bonomo RA.
Alsenani TA, et al. Among authors: introvigne ml.
Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0093022. doi: 10.1128/aac.00930-22. Epub 2023 Jan 5.
Antimicrob Agents Chemother. 2023.
PMID: 36602311
Free PMC article.
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Straightforward synthesis of chiral non-racemic α-boryl isocyanides.
Fini F, Zanni A, Introvigne ML, Stucchi M, Caselli E, Prati F.
Fini F, et al. Among authors: introvigne ml.
Org Biomol Chem. 2021 Aug 5;19(30):6687-6691. doi: 10.1039/d1ob00616a.
Org Biomol Chem. 2021.
PMID: 34286797
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1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase.
Caselli E, Fini F, Introvigne ML, Stucchi M, Taracila MA, Fish ER, Smolen KA, Rather PN, Powers RA, Wallar BJ, Bonomo RA, Prati F.
Caselli E, et al. Among authors: introvigne ml.
ACS Infect Dis. 2020 Jul 10;6(7):1965-1975. doi: 10.1021/acsinfecdis.0c00254. Epub 2020 Jun 24.
ACS Infect Dis. 2020.
PMID: 32502340
Free PMC article.
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α-Triazolylboronic Acids: A Promising Scaffold for Effective Inhibitors of KPCs.
Introvigne ML, Taracila MA, Prati F, Caselli E, Bonomo RA.
Introvigne ML, et al.
ChemMedChem. 2020 Jul 20;15(14):1283-1288. doi: 10.1002/cmdc.202000126. Epub 2020 Jun 22.
ChemMedChem. 2020.
PMID: 32459878
Free PMC article.
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