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Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design.
Bioorg Med Chem Lett. 2023 Jun 1;89:129277. doi: 10.1016/j.bmcl.2023.129277. Epub 2023 Apr 25.
Bioorg Med Chem Lett. 2023.
PMID: 37105490
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
Blaquiere N, Castanedo GM, Burch JD, Berezhkovskiy LM, Brightbill H, Brown S, Chan C, Chiang PC, Crawford JJ, Dong T, Fan P, Feng J, Ghilardi N, Godemann R, Gogol E, Grabbe A, Hole AJ, Hu B, Hymowitz SG, Alaoui Ismaili MH, Le H, Lee P, Lee W, Lin X, Liu N, McEwan PA, McKenzie B, Silvestre HL, Suto E, Sujatha-Bhaskar S, Wu G, Wu LC, Zhang Y, Zhong Z, Staben ST.
Blaquiere N, et al. Among authors: grabbe a.
J Med Chem. 2018 Aug 9;61(15):6801-6813. doi: 10.1021/acs.jmedchem.8b00678. Epub 2018 Jul 24.
J Med Chem. 2018.
PMID: 29940120
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Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants.
Cobo MM, Green G, Andritsou F, Baxter L, Evans Fry R, Grabbe A, Gursul D, Hoskin A, Mellado GS, van der Vaart M, Adams E, Bhatt A, Denk F, Hartley C, Slater R.
Cobo MM, et al. Among authors: grabbe a.
Nat Commun. 2022 Jul 8;13(1):3943. doi: 10.1038/s41467-022-31505-y.
Nat Commun. 2022.
PMID: 35803920
Free PMC article.
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SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk.
Abudula A, Grabbe A, Brechmann M, Polaschegg C, Herrmann N, Goldbeck I, Dittmann K, Wienands J.
Abudula A, et al. Among authors: grabbe a.
J Biol Chem. 2007 Sep 28;282(39):29059-29066. doi: 10.1074/jbc.M704043200. Epub 2007 Aug 6.
J Biol Chem. 2007.
PMID: 17681949
Free article.
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Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes.
Grabbe A, Wienands J.
Grabbe A, et al.
Blood. 2006 Dec 1;108(12):3761-8. doi: 10.1182/blood-2006-02-005397. Epub 2006 Aug 15.
Blood. 2006.
PMID: 16912232
Free article.
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