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Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.
Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z. Murashige D, et al. Among authors: yang s. Cell Metab. 2022 Nov 1;34(11):1749-1764.e7. doi: 10.1016/j.cmet.2022.09.008. Epub 2022 Oct 11. Cell Metab. 2022. PMID: 36223763 Free PMC article.
The small intestine shields the liver from fructose-induced steatosis.
Jang C, Wada S, Yang S, Gosis B, Zeng X, Zhang Z, Shen Y, Lee G, Arany Z, Rabinowitz JD. Jang C, et al. Among authors: yang s. Nat Metab. 2020 Jul;2(7):586-593. doi: 10.1038/s42255-020-0222-9. Epub 2020 Jun 22. Nat Metab. 2020. PMID: 32694791 Free PMC article.
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z. Hoshino A, et al. Among authors: yang s. Nature. 2019 Nov;575(7782):375-379. doi: 10.1038/s41586-019-1667-4. Epub 2019 Oct 16. Nature. 2019. PMID: 31618756 Free PMC article.
Functional effects of muscle PGC-1alpha in aged animals.
Yang S, Loro E, Wada S, Kim B, Tseng WJ, Li K, Khurana TS, Arany Z. Yang S, et al. Skelet Muscle. 2020 May 6;10(1):14. doi: 10.1186/s13395-020-00231-8. Skelet Muscle. 2020. PMID: 32375875 Free PMC article.
PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.
Liu LX, Rowe GC, Yang S, Li J, Damilano F, Chan MC, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann BK, Rabinowitz JD, Das S, Rosenzweig A, Arany Z. Liu LX, et al. Among authors: yang s. Circ Res. 2017 Dec 8;121(12):1370-1378. doi: 10.1161/CIRCRESAHA.117.311456. Epub 2017 Sep 19. Circ Res. 2017. PMID: 28928113 Free PMC article.
Endothelial pyruvate kinase M2 maintains vascular integrity.
Kim B, Jang C, Dharaneeswaran H, Li J, Bhide M, Yang S, Li K, Arany Z. Kim B, et al. Among authors: yang s. J Clin Invest. 2018 Oct 1;128(10):4543-4556. doi: 10.1172/JCI120912. Epub 2018 Sep 17. J Clin Invest. 2018. PMID: 30222136 Free PMC article.
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