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First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival.
Guijarro MV, Kellish PC, Dib PE, Paciaroni NG, Nawab A, Andring J, Kulemina L, Borrero NV, Modenutti C, Feely M, Nasri E, Seifert RP, Luo X, Bennett RL, Shabashvili D, Licht JD, McKenna R, Roitberg A, Huigens RW 3rd, Kaye FJ, Zajac-Kaye M. Guijarro MV, et al. Among authors: shabashvili d. JCI Insight. 2023 Apr 25;8(10):e158798. doi: 10.1172/jci.insight.158798. JCI Insight. 2023. PMID: 37097751 Free PMC article.
Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival.
Kellish P, Shabashvili D, Rahman MM, Nawab A, Guijarro MV, Zhang M, Cao C, Moussatche N, Boyle T, Antonia S, Reinhard M, Hartzell C, Jantz M, Mehta HJ, McFadden G, Kaye FJ, Zajac-Kaye M. Kellish P, et al. Among authors: shabashvili d. J Clin Invest. 2019 Apr 29;129(6):2279-2292. doi: 10.1172/JCI121323. eCollection 2019 Apr 29. J Clin Invest. 2019. PMID: 31033480 Free PMC article.
DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks.
Venugopal K, Feng Y, Nowialis P, Xu H, Shabashvili DE, Berntsen CM, Kaur P, Krajcik KI, Taragjini C, Zaroogian Z, Casellas Román HL, Posada LM, Gunaratne C, Li J, Dupéré-Richer D, Bennett RL, Pondugula S, Riva A, Cogle CR, Opavsky R, Law BK, Bhaduri-McIntosh S, Kubicek S, Staber PB, Licht JD, Bird JE, Guryanova OA. Venugopal K, et al. Among authors: shabashvili de. Clin Cancer Res. 2022 Feb 15;28(4):756-769. doi: 10.1158/1078-0432.CCR-21-2863. Clin Cancer Res. 2022. PMID: 34716195 Free PMC article.
Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.
Naffin-Olivos JL, Georgieva M, Goldfarb N, Madan-Lala R, Dong L, Bizzell E, Valinetz E, Brandt GS, Yu S, Shabashvili DE, Ringe D, Dunn BM, Petsko GA, Rengarajan J. Naffin-Olivos JL, et al. Among authors: shabashvili de. PLoS Pathog. 2014 May 15;10(5):e1004132. doi: 10.1371/journal.ppat.1004132. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24830429 Free PMC article.
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.
Feng Y, Yuan Q, Newsome RC, Robinson T, Bowman RL, Zuniga AN, Hall KN, Bernsten CM, Shabashvili DE, Krajcik KI, Gunaratne C, Zaroogian ZJ, Venugopal K, Casellas Roman HL, Levine RL, Chatila WK, Yaeger R, Riva A, Jobin C, Kopinke D, Avram D, Guryanova OA. Feng Y, et al. Among authors: shabashvili de. J Exp Med. 2023 Nov 6;220(11):e20230011. doi: 10.1084/jem.20230011. Epub 2023 Aug 24. J Exp Med. 2023. PMID: 37615936 Free PMC article.
Alterations to DNMT3A in Hematologic Malignancies.
Venugopal K, Feng Y, Shabashvili D, Guryanova OA. Venugopal K, et al. Among authors: shabashvili d. Cancer Res. 2021 Jan 15;81(2):254-263. doi: 10.1158/0008-5472.CAN-20-3033. Epub 2020 Oct 21. Cancer Res. 2021. PMID: 33087320 Free PMC article. Review.
Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).
Park HJ, Shabashvili D, Nekorchuk MD, Shyqyriu E, Jung JI, Ladd TB, Moore BD, Felsenstein KM, Golde TE, Kim SH. Park HJ, et al. Among authors: shabashvili d. J Biol Chem. 2012 Nov 23;287(48):40629-40. doi: 10.1074/jbc.M112.418442. Epub 2012 Oct 5. J Biol Chem. 2012. PMID: 23043097 Free PMC article.
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
Chen M, Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, Hollingshead M, Hunter KW, Kaye FJ, Hochwald SN, Marquez VE, Steeg P, Zajac-Kaye M. Chen M, et al. Among authors: shabashvili d. Mol Cancer Ther. 2012 Feb;11(2):370-82. doi: 10.1158/1535-7163.MCT-11-0458. Epub 2011 Dec 27. Mol Cancer Ther. 2012. PMID: 22203734 Free PMC article.