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Type-II IFN inhibits SARS-CoV-2 replication in human lung epithelial cells and ex vivo human lung tissues through indoleamine 2,3-dioxygenase-mediated pathways.
Yang D, Chan JF, Yoon C, Luk TY, Shuai H, Hou Y, Huang X, Hu B, Chai Y, Yuen TT, Liu Y, Zhu T, Liu H, Shi J, Wang Y, He Y, Sit KY, Au WK, Zhang AJ, Yuan S, Zhang BZ, Huang YW, Chu H. Yang D, et al. Among authors: sit ky. J Med Virol. 2024 Feb;96(2):e29472. doi: 10.1002/jmv.29472. J Med Virol. 2024. PMID: 38373201
A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.
Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM. Chan JF, et al. Among authors: sit ky. Cell Rep Med. 2022 Oct 18;3(10):100774. doi: 10.1016/j.xcrm.2022.100774. Epub 2022 Sep 29. Cell Rep Med. 2022. PMID: 36195094 Free PMC article.
Coronaviruses exploit a host cysteine-aspartic protease for replication.
Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang AJ, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Chu H, et al. Among authors: sit ky. Nature. 2022 Sep;609(7928):785-792. doi: 10.1038/s41586-022-05148-4. Epub 2022 Aug 3. Nature. 2022. PMID: 35922005
Concomitant Hepatorenal Dysfunction and Malnutrition in Valvular Heart Surgery: Long-Term Prognostic Implications for Death and Heart Failure.
Tse YK, Chandramouli C, Li HL, Yu SY, Wu MZ, Ren QW, Chen Y, Wong PF, Sit KY, Chan DT, Ho CK, Au WK, Li XL, Tse HF, Lam CSP, Yiu KH. Tse YK, et al. Among authors: sit ky. J Am Heart Assoc. 2022 May 17;11(10):e024060. doi: 10.1161/JAHA.121.024060. Epub 2022 May 16. J Am Heart Assoc. 2022. PMID: 35574957 Free PMC article.
28 results