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Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.
Lubow J, Levoir LM, Ralph DK, Belmont L, Contreras M, Cartwright-Acar CH, Kikawa C, Kannan S, Davidson E, Doranz BJ, Duran V, Sanchez DE, Sanz AM, Rosso F, Einav S, Matsen FA, Goo L. Lubow J, et al. Among authors: einav s. bioRxiv [Preprint]. 2023 Apr 10:2023.04.09.536175. doi: 10.1101/2023.04.09.536175. bioRxiv. 2023. PMID: 37090561 Free PMC article. Updated. Preprint.
Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.
Saul S, Karim M, Ghita L, Huang PT, Chiu W, Durán V, Lo CW, Kumar S, Bhalla N, Leyssen P, Alem F, Boghdeh NA, Tran DH, Cohen CA, Brown JA, Huie KE, Tindle C, Sibai M, Ye C, Khalil AM, Martinez-Sobrido L, Dye JM, Pinsky BA, Ghosh P, Das S, Solow-Cordero DE, Jin J, Wikswo JP, Jochmans D, Neyts J, Jonghe S, Narayanan A, Einav S. Saul S, et al. Among authors: einav s. bioRxiv [Preprint]. 2023 May 10:2021.05.15.444128. doi: 10.1101/2021.05.15.444128. bioRxiv. 2023. PMID: 34159337 Free PMC article. Updated. Preprint.
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity.
Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T. Gerninghaus J, et al. Among authors: einav s. bioRxiv [Preprint]. 2024 Feb 18:2024.02.18.580805. doi: 10.1101/2024.02.18.580805. bioRxiv. 2024. PMID: 38405908 Free PMC article. Preprint.
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
Karim M, Mishra M, Lo CW, Saul S, Cagirici HB, Tran DHN, Agrawal A, Ghita L, Ojha A, East MP, Gammeltoft KA, Sahoo MK, Johnson GL, Das S, Jochmans D, Cohen CA, Gottwein J, Dye J, Neff N, Pinsky BA, Laitinen T, Pantsar T, Poso A, Zanini F, Jonghe S, Asquith CRM, Einav S. Karim M, et al. Among authors: einav s. bioRxiv [Preprint]. 2024 Apr 17:2024.04.15.589676. doi: 10.1101/2024.04.15.589676. bioRxiv. 2024. PMID: 38659941 Free PMC article. Preprint.
Dissemination of clinical and scientific practice through social media: a SIAARTI consensus-based document.
Cortegiani A, Battaglini D, Amato G, Behr AU, Donadello K, Einav S, Frigo MG, Fullin G, Giannini A, Ippolito M, Marozzi F, Monzani R, Monti G, Schultz MJ, Torrano V, Villa G, Giarratano A. Cortegiani A, et al. Among authors: einav s. J Anesth Analg Crit Care. 2024 Mar 19;4(1):21. doi: 10.1186/s44158-024-00157-3. J Anesth Analg Crit Care. 2024. PMID: 38504319 Free PMC article. Review.
An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.
Westberg M, Su Y, Zou X, Huang P, Rustagi A, Garhyan J, Patel PB, Fernandez D, Wu Y, Hao C, Lo CW, Karim M, Ning L, Beck A, Saenkham-Huntsinger P, Tat V, Drelich A, Peng BH, Einav S, Tseng CK, Blish C, Lin MZ. Westberg M, et al. Among authors: einav s. Sci Transl Med. 2024 Mar 13;16(738):eadi0979. doi: 10.1126/scitranslmed.adi0979. Epub 2024 Mar 13. Sci Transl Med. 2024. PMID: 38478629
452 results