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NanoB2 to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET.
van den Bor J, Bergkamp ND, Anbuhl SM, Dekker F, Comez D, Perez Almeria CV, Bosma R, White CW, Kilpatrick LE, Hill SJ, Siderius M, Smit MJ, Heukers R. van den Bor J, et al. Among authors: heukers r. Cell Rep Methods. 2023 Mar 13;3(3):100422. doi: 10.1016/j.crmeth.2023.100422. eCollection 2023 Mar 27. Cell Rep Methods. 2023. PMID: 37056381 Free PMC article.
CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome.
de Wit RH, Heukers R, Brink HJ, Arsova A, Maussang D, Cutolo P, Strubbe B, Vischer HF, Bachelerie F, Smit MJ. de Wit RH, et al. Among authors: heukers r. J Pharmacol Exp Ther. 2017 Oct;363(1):35-44. doi: 10.1124/jpet.117.242735. Epub 2017 Aug 2. J Pharmacol Exp Ther. 2017. PMID: 28768817
The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth.
Heukers R, Fan TS, de Wit RH, van Senten JR, De Groof TWM, Bebelman MP, Lagerweij T, Vieira J, de Munnik SM, Smits-de Vries L, van Offenbeek J, Rahbar A, van Hoorick D, Söderberg-Naucler C, Würdinger T, Leurs R, Siderius M, Vischer HF, Smit MJ. Heukers R, et al. Oncogene. 2018 Jul;37(30):4110-4121. doi: 10.1038/s41388-018-0255-7. Epub 2018 Apr 30. Oncogene. 2018. PMID: 29706656 Free PMC article.
Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions.
Bobkov V, Zarca AM, Van Hout A, Arimont M, Doijen J, Bialkowska M, Toffoli E, Klarenbeek A, van der Woning B, van der Vliet HJ, Van Loy T, de Haard H, Schols D, Heukers R, Smit MJ. Bobkov V, et al. Among authors: heukers r. Biochem Pharmacol. 2018 Dec;158:413-424. doi: 10.1016/j.bcp.2018.10.014. Epub 2018 Oct 17. Biochem Pharmacol. 2018. PMID: 30342023 Free article.
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry.
Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, Van Loy T, Smit MJ, Schols D. Van Hout A, et al. Among authors: heukers r. Biochem Pharmacol. 2018 Dec;158:402-412. doi: 10.1016/j.bcp.2018.10.015. Epub 2018 Oct 17. Biochem Pharmacol. 2018. PMID: 30342024
Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs.
De Groof TWM, Bobkov V, Heukers R, Smit MJ. De Groof TWM, et al. Among authors: heukers r. Mol Cell Endocrinol. 2019 Mar 15;484:15-24. doi: 10.1016/j.mce.2019.01.021. Epub 2019 Jan 26. Mol Cell Endocrinol. 2019. PMID: 30690070 Free article. Review.
The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties.
van Senten JR, Bebelman MP, Fan TS, Heukers R, Bergkamp ND, van Gasselt P, Langemeijer EV, Slinger E, Lagerweij T, Rahbar A, Stigter-van Walsum M, Maussang D, Leurs R, Musters RJP, van Dongen GAMS, Söderberg-Nauclér C, Würdinger T, Siderius M, Smit MJ. van Senten JR, et al. Among authors: heukers r. J Biol Chem. 2019 Nov 1;294(44):16297-16308. doi: 10.1074/jbc.RA119.007796. Epub 2019 Sep 13. J Biol Chem. 2019. PMID: 31519750 Free PMC article.
41 results