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Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo.
Hashimoto K, Morishige K, Sawada K, Ogata S, Tahara M, Shimizu S, Sakata M, Tasaka K, Kimura T. Hashimoto K, et al. Among authors: kimura t. Biochem Biophys Res Commun. 2007 Apr 27;356(1):72-7. doi: 10.1016/j.bbrc.2007.02.102. Epub 2007 Feb 28. Biochem Biophys Res Commun. 2007. PMID: 17343825
Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation.
Arimoto-Ishida E, Sakata M, Sawada K, Nakayama M, Nishimoto F, Mabuchi S, Takeda T, Yamamoto T, Isobe A, Okamoto Y, Lengyel E, Suehara N, Morishige K, Kimura T. Arimoto-Ishida E, et al. Among authors: kimura t. Endocrinology. 2009 Sep;150(9):4306-15. doi: 10.1210/en.2008-1662. Epub 2009 Jun 4. Endocrinology. 2009. PMID: 19497979
mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary.
Mabuchi S, Kawase C, Altomare DA, Morishige K, Sawada K, Hayashi M, Tsujimoto M, Yamoto M, Klein-Szanto AJ, Schilder RJ, Ohmichi M, Testa JR, Kimura T. Mabuchi S, et al. Among authors: kimura t. Clin Cancer Res. 2009 Sep 1;15(17):5404-13. doi: 10.1158/1078-0432.CCR-09-0365. Epub 2009 Aug 18. Clin Cancer Res. 2009. PMID: 19690197 Free PMC article.
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