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Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer.
Eldehna WM, Salem R, Elsayed ZM, Al-Warhi T, Knany HR, Ayyad RR, Traiki TB, Abdulla MH, Ahmad R, Abdel-Aziz HA, El-Haggar R. Eldehna WM, et al. Among authors: ayyad rr. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1424-1435. doi: 10.1080/14756366.2021.1944127. J Enzyme Inhib Med Chem. 2021. PMID: 34176414 Free PMC article.
Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives.
Eldehna WM, Abou-Seri SM, El Kerdawy AM, Ayyad RR, Hamdy AM, Ghabbour HA, Ali MM, Abou El Ella DA. Eldehna WM, et al. Among authors: ayyad rr. Eur J Med Chem. 2016 May 4;113:50-62. doi: 10.1016/j.ejmech.2016.02.029. Epub 2016 Feb 15. Eur J Med Chem. 2016. PMID: 26922228
Development of 2-oindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells.
Eldehna WM, Abo-Ashour MF, Al-Warhi T, Al-Rashood ST, Alharbi A, Ayyad RR, Al-Khayal K, Abdulla M, Abdel-Aziz HA, Ahmad R, El-Haggar R. Eldehna WM, et al. Among authors: ayyad rr. J Enzyme Inhib Med Chem. 2021 Dec;36(1):319-328. doi: 10.1080/14756366.2020.1862100. J Enzyme Inhib Med Chem. 2021. PMID: 33345633 Free PMC article.
Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors.
El-Helby AA, Sakr H, Ayyad RR, Mahdy HA, Khalifa MM, Belal A, Rashed M, El-Sharkawy A, Metwaly AM, Elhendawy MA, Radwan MM, ElSohly MA, Eissa IH. El-Helby AA, et al. Among authors: ayyad rr. Bioorg Chem. 2020 Oct;103:104233. doi: 10.1016/j.bioorg.2020.104233. Epub 2020 Aug 26. Bioorg Chem. 2020. PMID: 32882440
Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5-[(4-chloro/2,4-dichloro)benzylidene]thiazolidine-2,4-dione derivatives as VEGFR-2 inhibitors.
El-Adl K, El-Helby AA, Sakr H, Ayyad RR, Mahdy HA, Nasser M, Abulkhair HS, El-Hddad SSA. El-Adl K, et al. Among authors: ayyad rr. Arch Pharm (Weinheim). 2021 Feb;354(2):e2000279. doi: 10.1002/ardp.202000279. Epub 2020 Oct 19. Arch Pharm (Weinheim). 2021. PMID: 33073374
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