Garavaglia S - Search Results

1

A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment.

Boumya S, Fallarini S, Siragusa S, Petrarolo G, Aprile S, Audrito V, La Motta C, Garavaglia S, Moro L, Pinton G. Boumya S, et al. Among authors: garavaglia s. Int J Mol Sci. 2023 Apr 3;24(7):6689. doi: 10.3390/ijms24076689. Int J Mol Sci. 2023. PMID: 37047661 Free PMC article.

2

A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro.

Gelardi ELM, Colombo G, Picarazzi F, Ferraris DM, Mangione A, Petrarolo G, Aronica E, Rizzi M, Mori M, La Motta C, Garavaglia S. Gelardi ELM, et al. Among authors: garavaglia s. Cancers (Basel). 2021 Jan 19;13(2):356. doi: 10.3390/cancers13020356. Cancers (Basel). 2021. PMID: 33478031 Free PMC article.

3

Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family.

Quattrini L, Gelardi ELM, Petrarolo G, Colombo G, Ferraris DM, Picarazzi F, Rizzi M, Garavaglia S, La Motta C. Quattrini L, et al. Among authors: garavaglia s. ACS Med Chem Lett. 2020 Mar 25;11(5):963-970. doi: 10.1021/acsmedchemlett.9b00686. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435412 Free PMC article.

4

Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.

Quattrini L, Gelardi ELM, Coviello V, Sartini S, Ferraris DM, Mori M, Nakano I, Garavaglia S, La Motta C. Quattrini L, et al. Among authors: garavaglia s. J Med Chem. 2020 May 14;63(9):4603-4616. doi: 10.1021/acs.jmedchem.9b01910. Epub 2020 Apr 20. J Med Chem. 2020. PMID: 32223240

5

A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN/NAD⁺ salvage pathway in the nucleus.

Grolla AA, Miggiano R, Di Marino D, Bianchi M, Gori A, Orsomando G, Gaudino F, Galli U, Del Grosso E, Mazzola F, Angeletti C, Guarneri M, Torretta S, Calabrò M, Boumya S, Fan X, Colombo G, Travelli C, Rocchio F, Aronica E, Wohlschlegel JA, Deaglio S, Rizzi M, Genazzani AA, Garavaglia S. Grolla AA, et al. Among authors: garavaglia s. J Biol Chem. 2020 Mar 13;295(11):3635-3651. doi: 10.1074/jbc.RA119.010571. Epub 2020 Jan 27. J Biol Chem. 2020. PMID: 31988240 Free PMC article.

6

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.

Li J, Garavaglia S, Ye Z, Moretti A, Belyaeva OV, Beiser A, Ibrahim M, Wilk A, McClellan S, Klyuyeva AV, Goggans KR, Kedishvili NY, Salter EA, Wierzbicki A, Migaud ME, Mullett SJ, Yates NA, Camacho CJ, Rizzi M, Sobol RW. Li J, et al. Among authors: garavaglia s. Commun Biol. 2021 Dec 21;4(1):1420. doi: 10.1038/s42003-021-02949-7. Commun Biol. 2021. PMID: 34934174 Free PMC article.

7

Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis.

Gelardi ELM, Caprioglio D, Colombo G, Del Grosso E, Mazzoletti D, Mattoteia D, Salamone S, Ferraris DM, Aronica E, Nato G, Buffo A, Rizzi M, Magrassi L, Minassi A, Garavaglia S. Gelardi ELM, et al. Among authors: garavaglia s. Commun Biol. 2022 Sep 1;5(1):895. doi: 10.1038/s42003-022-03834-7. Commun Biol. 2022. PMID: 36050388 Free PMC article.

8

Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD⁺ and retinoic acid.

Moretti A, Li J, Donini S, Sobol RW, Rizzi M, Garavaglia S. Moretti A, et al. Among authors: garavaglia s. Sci Rep. 2016 Oct 19;6:35710. doi: 10.1038/srep35710. Sci Rep. 2016. PMID: 27759097 Free PMC article.

9

The structure of Rigidoporus lignosus Laccase containing a full complement of copper ions, reveals an asymmetrical arrangement for the T3 copper pair.

Garavaglia S, Cambria MT, Miglio M, Ragusa S, Iacobazzi V, Palmieri F, D'Ambrosio C, Scaloni A, Rizzi M. Garavaglia S, et al. J Mol Biol. 2004 Oct 1;342(5):1519-31. doi: 10.1016/j.jmb.2004.07.100. J Mol Biol. 2004. PMID: 15364578

10

Extracellular NAD⁺ enhances PARP-dependent DNA repair capacity independently of CD73 activity.

Wilk A, Hayat F, Cunningham R, Li J, Garavaglia S, Zamani L, Ferraris DM, Sykora P, Andrews J, Clark J, Davis A, Chaloin L, Rizzi M, Migaud M, Sobol RW. Wilk A, et al. Among authors: garavaglia s. Sci Rep. 2020 Jan 20;10(1):651. doi: 10.1038/s41598-020-57506-9. Sci Rep. 2020. PMID: 31959836 Free PMC article.

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