Weng JH - Search Results

1

Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors.

Weng JH, Ma W, Wu J, Sharma PK, Silletti S, McCammon JA, Taylor S. Weng JH, et al. ACS Chem Biol. 2023 Apr 21;18(4):810-821. doi: 10.1021/acschembio.2c00868. Epub 2023 Apr 12. ACS Chem Biol. 2023. PMID: 37043829 Free PMC article.

2

Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP.

Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. Lu TW, et al. Among authors: weng jh. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16347-16356. doi: 10.1073/pnas.1906036116. Epub 2019 Jul 30. Proc Natl Acad Sci U S A. 2019. PMID: 31363049 Free PMC article.

3

Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery.

Taylor SS, Kaila-Sharma P, Weng JH, Aoto P, Schmidt SH, Knapp S, Mathea S, Herberg FW. Taylor SS, et al. Among authors: weng jh. Front Mol Neurosci. 2020 Oct 6;13:538219. doi: 10.3389/fnmol.2020.538219. eCollection 2020. Front Mol Neurosci. 2020. PMID: 33122997 Free PMC article.

4

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.

Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS. Lu TW, et al. Among authors: weng jh. PLoS Biol. 2020 Dec 28;18(12):e3001018. doi: 10.1371/journal.pbio.3001018. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33370777 Free PMC article.

5

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.

Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS. Schmidt SH, et al. Among authors: weng jh. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2100844118. doi: 10.1073/pnas.2100844118. Proc Natl Acad Sci U S A. 2021. PMID: 34088839 Free PMC article.

6

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.

Weng JH, Aoto PC, Lorenz R, Wu J, Schmidt SH, Manschwetus JT, Kaila-Sharma P, Silletti S, Mathea S, Chatterjee D, Knapp S, Herberg FW, Taylor SS. Weng JH, et al. PLoS Biol. 2022 Feb 22;20(2):e3001427. doi: 10.1371/journal.pbio.3001427. eCollection 2022 Feb. PLoS Biol. 2022. PMID: 35192607 Free PMC article.

7

Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order-Disorder Transition Upon Activation.

Weng JH, Trilling CR, Kaila Sharma P, Störmer E, Wu J, Herberg FW, Taylor SS. Weng JH, et al. J Mol Biol. 2023 Jun 15;435(12):167999. doi: 10.1016/j.jmb.2023.167999. Epub 2023 Feb 9. J Mol Biol. 2023. PMID: 36764356 Free article.

8

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. Jones AC, et al. Among authors: weng jh. bioRxiv [Preprint]. 2023 Mar 16:2023.03.16.532226. doi: 10.1101/2023.03.16.532226. bioRxiv. 2023. PMID: 36993163 Free PMC article. Updated. Preprint.

9

RedOx regulation of LRRK2 kinase activity by active site cysteines.

Trilling CR, Weng JH, Sharma PK, Nolte V, Wu J, Ma W, Boassa D, Taylor SS, Herberg FW. Trilling CR, et al. Among authors: weng jh. NPJ Parkinsons Dis. 2024 Apr 3;10(1):75. doi: 10.1038/s41531-024-00683-5. NPJ Parkinsons Dis. 2024. PMID: 38570484 Free PMC article.

10

Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation.

Chen ES, Weng JH, Chen YH, Wang SC, Liu XX, Huang WC, Matsui T, Kawano Y, Liao JH, Lim LH, Bessho Y, Huang KF, Wu WJ, Tsai MD. Chen ES, et al. Among authors: weng jh. Biochemistry. 2017 Sep 26;56(38):5112-5124. doi: 10.1021/acs.biochem.7b00689. Epub 2017 Sep 15. Biochemistry. 2017. PMID: 28858528

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