Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages.
Meinen S, Barzaghi P, Lin S, Lochmüller H, Ruegg MA.
Meinen S, et al. Among authors: lin s.
J Cell Biol. 2007 Mar 26;176(7):979-93. doi: 10.1083/jcb.200611152.
J Cell Biol. 2007.
PMID: 17389231
Free PMC article.
We have previously shown in mouse models for MDC1A that muscle-specific overexpression of a miniaturized form of agrin (mini-agrin), which binds to dystroglycan but not to alpha7beta1 integrin, substantially ameliorates the disease (Moll, J., P. Barzaghi, S. Lin, G. …
We have previously shown in mouse models for MDC1A that muscle-specific overexpression of a miniaturized form of agrin (mini-agrin), which b …