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In silico and in vitro assessment of anti-Trypanosoma cruzi efficacy, genotoxicity and pharmacokinetics of pentasubstituted pyrrolic Atorvastatin-aminoquinoline hybrid compounds.
Araujo-Lima CF, Carvalho RCC, Peres RB, Fiuza LFA, Galvão BVD, Castelo-Branco FS, Bastos MM, Boechat N, Felzenszwalb I, Soeiro MNC. Araujo-Lima CF, et al. Among authors: peres rb. Acta Trop. 2023 Jun;242:106924. doi: 10.1016/j.actatropica.2023.106924. Epub 2023 Apr 8. Acta Trop. 2023. PMID: 37037291
Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration.
Ferreira de Almeida Fiuza L, Peres RB, Simões-Silva MR, da Silva PB, Batista DDGJ, da Silva CF, Nefertiti Silva da Gama A, Krishna Reddy TR, Soeiro MNC. Ferreira de Almeida Fiuza L, et al. Among authors: peres rb. Eur J Med Chem. 2018 Apr 10;149:257-268. doi: 10.1016/j.ejmech.2018.02.020. Epub 2018 Feb 23. Eur J Med Chem. 2018. PMID: 29501946 Free article.
New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations.
Leite DI, Fontes FV, Bastos MM, Hoelz LVB, Bianco MDCAD, de Oliveira AP, da Silva PB, da Silva CF, Batista DDGJ, da Gama ANS, Peres RB, Villar JDF, Soeiro MNC, Boechat N. Leite DI, et al. Among authors: peres rb. Chem Biol Drug Des. 2018 Sep;92(3):1670-1682. doi: 10.1111/cbdd.13333. Epub 2018 Jun 13. Chem Biol Drug Des. 2018. PMID: 29745048
Repurposing Strategy of Atorvastatin against Trypanosoma cruzi: In Vitro Monotherapy and Combined Therapy with Benznidazole Exhibit Synergistic Trypanocidal Activity.
Araujo-Lima CF, Peres RB, Silva PB, Batista MM, Aiub CAF, Felzenszwalb I, Soeiro MNC. Araujo-Lima CF, et al. Among authors: peres rb. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00979-18. doi: 10.1128/AAC.00979-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29987140 Free PMC article.
Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi.
De Araújo JS, da Silva PB, Batista MM, Peres RB, Cardoso-Santos C, Kalejaiye TD, Munday JC, De Heuvel E, Sterk GJ, Augustyns K, Salado IG, Matheeussen A, De Esch I, De Koning HP, Leurs R, Maes L, Soeiro MNC. De Araújo JS, et al. Among authors: peres rb. J Antimicrob Chemother. 2020 Apr 1;75(4):958-967. doi: 10.1093/jac/dkz516. J Antimicrob Chemother. 2020. PMID: 31860098
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies.
Fonseca-Berzal C, da Silva CF, Batista DDGJ, de Oliveira GM, Cumella J, Batista MM, Peres RB, Silva da Gama Nefertiti A, Escario JA, Gómez-Barrio A, Arán VJ, Soeiro MNC. Fonseca-Berzal C, et al. Among authors: peres rb. Parasitology. 2020 Sep;147(11):1216-1228. doi: 10.1017/S0031182020000955. Epub 2020 Jun 12. Parasitology. 2020. PMID: 32530391 Free PMC article.
Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity against Intracellular Trypanosomatids.
de Araújo JS, Peres RB, Bernardino da Silva P, Batista MM, Sterk GJ, Maes L, Caljon G, Leurs R, de Koning HP, Kalejaiye TD, Soeiro MNC. de Araújo JS, et al. Among authors: peres rb. Antimicrob Agents Chemother. 2021 Feb 17;65(3):e00960-20. doi: 10.1128/AAC.00960-20. Print 2021 Feb 17. Antimicrob Agents Chemother. 2021. PMID: 33361300 Free PMC article.
Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi.
Rocha-Hasler M, de Oliveira GM, da Gama AN, Fiuza LFA, Fesser AF, Cal M, Rocchetti R, Peres RB, Guan XL, Kaiser M, Soeiro MNC, Mäser P. Rocha-Hasler M, et al. Among authors: peres rb. Front Cell Infect Microbiol. 2021 Mar 4;11:617917. doi: 10.3389/fcimb.2021.617917. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 33747979 Free PMC article.
21 results