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In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
De Giorgi M, Park SH, Castoreno A, Cao M, Hurley A, Saxena L, Chuecos MA, Walkey CJ, Doerfler AM, Furgurson MN, Ljungberg MC, Patel KR, Hyde S, Chickering T, Lefebvre S, Wassarman K, Miller P, Qin J, Schlegel MK, Zlatev I, Li RG, Kim J, Martin JF, Bissig KD, Jadhav V, Bao G, Lagor WR. De Giorgi M, et al. Among authors: chickering t. bioRxiv [Preprint]. 2023 Jul 29:2023.07.26.550728. doi: 10.1101/2023.07.26.550728. bioRxiv. 2023. PMID: 37546995 Free PMC article. Preprint.
RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.
Subramanian M, McIninch J, Zlatev I, Schlegel MK, Kaittanis C, Nguyen T, Agarwal S, Racie T, Alvarado MA, Wassarman K, Collins TS, Chickering T, Brown CR, Schmidt K, Castoreno AB, Shulga-Morskaya S, Stamenova E, Buckowing K, Berman D, Barry JD, Bisbe A, Maier MA, Fitzgerald K, Jadhav V. Subramanian M, et al. Among authors: chickering t. Nat Commun. 2023 Apr 8;14(1):1970. doi: 10.1038/s41467-023-37774-5. Nat Commun. 2023. PMID: 37031257 Free PMC article.
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Brown KM, Nair JK, Janas MM, Anglero-Rodriguez YI, Dang LTH, Peng H, Theile CS, Castellanos-Rizaldos E, Brown C, Foster D, Kurz J, Allen J, Maganti R, Li J, Matsuda S, Stricos M, Chickering T, Jung M, Wassarman K, Rollins J, Woods L, Kelin A, Guenther DC, Mobley MW, Petrulis J, McDougall R, Racie T, Bombardier J, Cha D, Agarwal S, Johnson L, Jiang Y, Lentini S, Gilbert J, Nguyen T, Chigas S, LeBlanc S, Poreci U, Kasper A, Rogers AB, Chong S, Davis W, Sutherland JE, Castoreno A, Milstein S, Schlegel MK, Zlatev I, Charisse K, Keating M, Manoharan M, Fitzgerald K, Wu JT, Maier MA, Jadhav V. Brown KM, et al. Among authors: chickering t. Nat Biotechnol. 2022 Oct;40(10):1500-1508. doi: 10.1038/s41587-022-01334-x. Epub 2022 Jun 2. Nat Biotechnol. 2022. PMID: 35654979
RNAs Containing Carbocyclic Ribonucleotides.
Akabane-Nakata M, Chickering T, Harp JM, Schlegel MK, Matsuda S, Egli M, Manoharan M. Akabane-Nakata M, et al. Among authors: chickering t. Org Lett. 2022 Jan 21;24(2):525-530. doi: 10.1021/acs.orglett.1c03936. Epub 2021 Dec 27. Org Lett. 2022. PMID: 34958225
Twisted gastrulation can function as a BMP antagonist.
Chang C, Holtzman DA, Chau S, Chickering T, Woolf EA, Holmgren LM, Bodorova J, Gearing DP, Holmes WE, Brivanlou AH. Chang C, et al. Among authors: chickering t. Nature. 2001 Mar 22;410(6827):483-7. doi: 10.1038/35068583. Nature. 2001. PMID: 11260717
Isolation and characterization of the notch ligand delta4.
Rao PK, Dorsch M, Chickering T, Zheng G, Jiang C, Goodearl A, Kadesch T, McCarthy S. Rao PK, et al. Among authors: chickering t. Exp Cell Res. 2000 Nov 1;260(2):379-86. doi: 10.1006/excr.2000.5034. Exp Cell Res. 2000. PMID: 11035934 Free article.
19 results