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Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets.
Le TDV, Fathi P, Watters AB, Ellis BJ, Besing GK, Bozadjieva-Kramer N, Perez MB, Sullivan AI, Rose JP, Baggio LL, Koehler J, Brown JL, Bales MB, Nwaba KG, Campbell JE, Drucker DJ, Potthoff MJ, Seeley RJ, Ayala JE. Le TDV, et al. Among authors: seeley rj. Mol Metab. 2023 Jun;72:101718. doi: 10.1016/j.molmet.2023.101718. Epub 2023 Apr 7. Mol Metab. 2023. PMID: 37030441 Free PMC article.
Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets.
Le TDV, Fathi P, Watters AB, Ellis BJ, Bozadjieva-Kramer N, Perez MB, Sullivan AI, Rose JP, Baggio LL, Koehler J, Brown JL, Bales MB, Nwaba KG, Campbell JE, Drucker DJ, Potthoff MJ, Seeley RJ, Ayala JE. Le TDV, et al. Among authors: seeley rj. bioRxiv [Preprint]. 2023 Jan 3:2023.01.03.522509. doi: 10.1101/2023.01.03.522509. bioRxiv. 2023. PMID: 36711605 Free PMC article. Updated. Preprint.
Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance.
Bozadjieva-Kramer N, Shin JH, Li Z, Rupp AC, Miller N, Kernodle S, Lanthier N, Henry P, Seshadri N, Myronovych A, MacDougald OA, O'Rourke RW, Kohli R, Burant CF, Rothberg AE, Seeley RJ. Bozadjieva-Kramer N, et al. Among authors: seeley rj. JCI Insight. 2024 Apr 8;9(7):e174164. doi: 10.1172/jci.insight.174164. JCI Insight. 2024. PMID: 38587078 Free PMC article.
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism.
Sjøberg KA, Sigvardsen CM, Alvarado-Diaz A, Andersen NR, Larance M, Seeley RJ, Schjerling P, Knudsen JG, Katzilieris-Petras G, Clemmensen C, Jørgensen SB, De Bock K, Richter EA. Sjøberg KA, et al. Among authors: seeley rj. Cell Metab. 2023 Aug 8;35(8):1327-1340.e5. doi: 10.1016/j.cmet.2023.06.016. Epub 2023 Jul 19. Cell Metab. 2023. PMID: 37473755
Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models.
Rupp AC, Tomlinson AJ, Affinati AH, Yacawych WT, Duensing AM, True C, Lindsley SR, Kirigiti MA, MacKenzie A, Polex-Wolf J, Li C, Knudsen LB, Seeley RJ, Olson DP, Kievit P, Myers MG Jr. Rupp AC, et al. Among authors: seeley rj. J Clin Invest. 2023 Oct 2;133(19):e157515. doi: 10.1172/JCI157515. J Clin Invest. 2023. PMID: 37581939 Free PMC article.
408 results