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Specific human leukocyte antigen class I genotypes predict prognosis in resected pancreatic adenocarcinoma: a retrospective cohort study.
Wen C, Zhang L, Yang Y, Jin Y, Ren D, Zhang Z, Zou S, Li F, Sun H, Jin J, Lu X, Xie J, Cheng D, Xu Z, Chen H, Mao B, Zhang J, Wang J, Deng X, Peng C, Li H, Jiang C, Lin L, Zhang H, Chen H, Shen B, Zhan Q. Wen C, et al. Among authors: mao b. Int J Surg. 2023 Jul 1;109(7):1941-1952. doi: 10.1097/JS9.0000000000000264. Int J Surg. 2023. PMID: 37026827 Free PMC article.
Tyrosinase deficiency impairs social novelty preference in mice.
Aizawa S, Yamamuro Y. Aizawa S, et al. Neuroreport. 2024 May 30. doi: 10.1097/WNR.0000000000002055. Online ahead of print. Neuroreport. 2024. PMID: 38829918
We also found that the hippocampal expression of genes involved in catecholamine metabolism, such as monoamine oxidase A and catechol-O-methyltransferase, were significantly decreased in tyrosinase-deficient B10-c mice. ...
We also found that the hippocampal expression of genes involved in catecholamine metabolism, such as monoamine oxidase A and c …
Targeting Biometals in Alzheimer's Disease with Metal Chelating Agents Including Coumarin Derivatives.
Gucký A, Hamuľaková S. Gucký A, et al. CNS Drugs. 2024 Jun 3. doi: 10.1007/s40263-024-01093-0. Online ahead of print. CNS Drugs. 2024. PMID: 38829443 Review.
Various coumarin derivatives match this description and apart from being able to chelate metal ions, they exhibit the capacity to inhibit cholinesterases (ChEs) and monoamine oxidase B (MAO-B) while also possessing antioxidant, anti-inflammatory, and n …
Various coumarin derivatives match this description and apart from being able to chelate metal ions, they exhibit the capacity to inhibit ch …
Computational identification of potential acetylcholinesterase (AChE) and monoamine oxidase-B inhibitors from Vitis vinifera: a case study of Alzheimer's disease (AD).
Sofela SO, Ibrahim A, Ogbodo UC, Bodun DS, Nwankwo DO, Mafimisebi M, Abdulrasheed B, Balogun T, Opeyemi I. Sofela SO, et al. In Silico Pharmacol. 2024 May 31;12(1):49. doi: 10.1007/s40203-024-00214-3. eCollection 2024. In Silico Pharmacol. 2024. PMID: 38828442
At the same time, the currently available anti-cholinesterase (AChE) and monoamine oxidase-B (MAO-B) for the treatment of AD can only improve the clinical symptoms while the recently approved immunotherapy agent "remains questionable. ...These compound …
At the same time, the currently available anti-cholinesterase (AChE) and monoamine oxidase-B (MAO-B) for the tre …
Pharmacological and behavioural effects of tryptamines present in psilocybin-containing mushrooms.
Rakoczy RJ, Runge GN, Sen AK, Sandoval O, Wells HG, Nguyen Q, Roberts BR, Sciortino JH, Gibbons WJ Jr, Friedberg LM, Jones JA, McMurray MS. Rakoczy RJ, et al. Br J Pharmacol. 2024 Jun 2. doi: 10.1111/bph.16466. Online ahead of print. Br J Pharmacol. 2024. PMID: 38825326
KEY RESULTS: In vitro enzyme kinetics assays found that all compounds had nearly identical rates of dephosphorylation via alkaline phosphatase and metabolism by monoamine oxidase. Further, we found that only the dephosphorylated products of baeocystin and norbaeocys …
KEY RESULTS: In vitro enzyme kinetics assays found that all compounds had nearly identical rates of dephosphorylation via alkaline phosphata …
Non-cytotoxic 3-Acetylcoumarin as an Attractive Target for Human Monoamine Oxidase (HMAO) Enzymes.
Aghimien MO, Kolawole Q, Igbinoba PO, Musa MA, Latinwo L. Aghimien MO, et al. Anticancer Res. 2024 Jun;44(6):2335-2341. doi: 10.21873/anticanres.17040. Anticancer Res. 2024. PMID: 38821578
BACKGROUND/AIM: Coumarins are a broad class of naturally occurring oxygen-heterocyclic compounds found in plants with diverse biological properties, making them attractive for evaluation as novel therapeutic agents. We herein report the in vitro cytotoxic and monoamine …
BACKGROUND/AIM: Coumarins are a broad class of naturally occurring oxygen-heterocyclic compounds found in plants with diverse biological pro …
Design and discovery of anthranilamide derivatives as a potential treatment for neurodegenerative disorders via targeting cholinesterases and monoamine oxidases.
Zaib S, Khan I, Ali HS, Younas MT, Ibrar A, Al-Odayni AB, Al-Kahtani AA. Zaib S, et al. Int J Biol Macromol. 2024 May 29:132748. doi: 10.1016/j.ijbiomac.2024.132748. Online ahead of print. Int J Biol Macromol. 2024. PMID: 38821306
Neurodegenerative diseases with progressive cellular loss of the central nervous system and elusive disease etiology provide a continuous impetus to explore drug discovery programmes aiming at identifying robust and effective inhibitors of cholinesterase and monoamine o …
Neurodegenerative diseases with progressive cellular loss of the central nervous system and elusive disease etiology provide a continuous im …
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization.
La Spada G, Miniero DV, Rullo M, Cipolloni M, Delre P, Colliva C, Colella M, Leonetti F, Liuzzi GM, Mangiatordi GF, Giacchè N, Pisani L. La Spada G, et al. Eur J Med Chem. 2024 May 19;274:116511. doi: 10.1016/j.ejmech.2024.116511. Online ahead of print. Eur J Med Chem. 2024. PMID: 38820854 Free article.
A structure-based drug design approach was focused on incorporating phenyl ring heterocyclic bioisosteres into coumarin derivative 1, previously reported as potent dual AChE-MAO B inhibitor, with the aim of improving drug-like features. Structure-activity relationsh …
A structure-based drug design approach was focused on incorporating phenyl ring heterocyclic bioisosteres into coumarin derivative 1, previo …
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