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Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial).
Mazer CD, Siadati-Fini N, Boehm J, Wirth F, Myjavec A, Brown CD, Koyner JL, Boening A, Engelman DT, Larsson TE, Renfurm R, de Varennes B, Noiseux N, Thielmann M, Lamy A, Laflamme M, von Groote T, Ronco C, Zarbock A. Mazer CD, et al. Among authors: larsson te. BMJ Open. 2023 Apr 6;13(4):e068363. doi: 10.1136/bmjopen-2022-068363. BMJ Open. 2023. PMID: 37024249 Free PMC article.
A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy.
Arbel Rubinstein T, Reuveni I, Hesin A, Klein-Goldberg A, Olauson H, Larsson TE, Abraham CR, Zeldich E, Bosch A, Chillón M, Hollander KS, Shabtay-Orbach A, Vainer GW, Wolf I, Rubinek T. Arbel Rubinstein T, et al. Among authors: larsson te. Cancers (Basel). 2021 Dec 15;13(24):6297. doi: 10.3390/cancers13246297. Cancers (Basel). 2021. PMID: 34944918 Free PMC article.
Mechanism-based modeling of the effect of a novel inhibitor of vascular adhesion protein-1 on albuminuria and renal function markers in patients with diabetic kidney disease.
Hoefman S, Snelder N, van Noort M, Garcia-Hernandez A, Onkels H, Larsson TE, Bergmann KR. Hoefman S, et al. Among authors: larsson te. J Pharmacokinet Pharmacodyn. 2021 Feb;48(1):21-38. doi: 10.1007/s10928-020-09716-x. Epub 2020 Sep 14. J Pharmacokinet Pharmacodyn. 2021. PMID: 32929612 Free PMC article.
Carbazate modified dextrans as scavengers for carbonylated proteins.
Zhou B, Gao M, Feng X, Huang L, Huang Q, Kootala S, Larsson TE, Zheng L, Bowden T. Zhou B, et al. Among authors: larsson te. Carbohydr Polym. 2020 Mar 15;232:115802. doi: 10.1016/j.carbpol.2019.115802. Epub 2019 Dec 28. Carbohydr Polym. 2020. PMID: 31952601
Klotho controls the brain-immune system interface in the choroid plexus.
Zhu L, Stein LR, Kim D, Ho K, Yu GQ, Zhan L, Larsson TE, Mucke L. Zhu L, et al. Among authors: larsson te. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11388-E11396. doi: 10.1073/pnas.1808609115. Epub 2018 Nov 9. Proc Natl Acad Sci U S A. 2018. PMID: 30413620 Free PMC article.
Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial.
de Zeeuw D, Renfurm RW, Bakris G, Rossing P, Perkovic V, Hou FF, Nangaku M, Sharma K, Heerspink HJL, Garcia-Hernandez A, Larsson TE. de Zeeuw D, et al. Among authors: larsson te. Lancet Diabetes Endocrinol. 2018 Dec;6(12):925-933. doi: 10.1016/S2213-8587(18)30289-4. Epub 2018 Nov 6. Lancet Diabetes Endocrinol. 2018. PMID: 30413396 Clinical Trial.
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