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A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion.
Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT. Kofuji S, et al. Among authors: edinger al. Biochem Biophys Res Commun. 2024 Jul 23;718:149981. doi: 10.1016/j.bbrc.2024.149981. Epub 2024 Apr 27. Biochem Biophys Res Commun. 2024. PMID: 38735134
Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy.
Vöing K, Michgehl U, Mertens ND, Picciotto C, Maywald ML, Goretzko J, Waimann S, Gilhaus K, Rogg M, Schell C, Klingauf J, Tsytsyura Y, Hansen U, van Marck V, Edinger AL, Vollenbröker B, Rescher U, Braun DA, George B, Weide T, Pavenstädt H. Vöing K, et al. Among authors: edinger al. J Am Soc Nephrol. 2023 Jul 1;34(7):1191-1206. doi: 10.1681/ASN.0000000000000126. Epub 2023 Apr 5. J Am Soc Nephrol. 2023. PMID: 37022133
Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity.
Jayashankar V, Selwan E, Hancock SE, Verlande A, Goodson MO, Eckenstein KH, Milinkeviciute G, Hoover BM, Chen B, Fleischman AG, Cramer KS, Hanessian S, Masri S, Turner N, Edinger AL. Jayashankar V, et al. Among authors: edinger al. EMBO Mol Med. 2021 Aug 9;13(8):e13086. doi: 10.15252/emmm.202013086. Epub 2021 Jul 7. EMBO Mol Med. 2021. PMID: 34231322 Free PMC article.
Biocompatible Chemotherapy for Leukemia by Acid-Cleavable, PEGylated FTY720.
Kemp JA, Keebaugh A, Edson JA, Chow D, Kleinman MT, Chew YC, McCracken AN, Edinger AL, Kwon YJ. Kemp JA, et al. Among authors: edinger al. Bioconjug Chem. 2020 Mar 18;31(3):673-684. doi: 10.1021/acs.bioconjchem.9b00822. Epub 2020 Jan 27. Bioconjug Chem. 2020. PMID: 31986014
Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A.
Garsi JB, Vece V, Sernissi L, Auger-Morin C, Hanessian S, McCracken AN, Selwan E, Ramirez C, Dahal A, Romdhane NB, Finicle BT, Edinger AL. Garsi JB, et al. Among authors: edinger al. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2681-2685. doi: 10.1016/j.bmcl.2019.07.023. Epub 2019 Jul 19. Bioorg Med Chem Lett. 2019. PMID: 31383588 Free PMC article.
70 results