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Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4.
Chauhan J, Grandits M, Palhares LCGF, Mele S, Nakamura M, López-Abente J, Crescioli S, Laddach R, Romero-Clavijo P, Cheung A, Stavraka C, Chenoweth AM, Sow HS, Chiaruttini G, Gilbert AE, Dodev T, Koers A, Pellizzari G, Ilieva KM, Man F, Ali N, Hobbs C, Lombardi S, Lionarons DA, Gould HJ, Beavil AJ, Geh JLC, MacKenzie Ross AD, Healy C, Calonje E, Downward J, Nestle FO, Tsoka S, Josephs DH, Blower PJ, Karagiannis P, Lacy KE, Spicer J, Karagiannis SN, Bax HJ. Chauhan J, et al. Among authors: beavil aj. Nat Commun. 2023 Apr 25;14(1):2192. doi: 10.1038/s41467-023-37811-3. Nat Commun. 2023. PMID: 37185332 Free PMC article.
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Mitropoulou AN, Ceska T, Heads JT, Beavil AJ, Henry AJ, McDonnell JM, Sutton BJ, Davies AM. Mitropoulou AN, et al. Among authors: beavil aj. Acta Crystallogr F Struct Biol Commun. 2020 Mar 1;76(Pt 3):116-129. doi: 10.1107/S2053230X20001466. Epub 2020 Mar 2. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 32133997 Free PMC article.
Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.
Mitropoulou AN, Bowen H, Dodev TS, Davies AM, Bax HJ, Beavil RL, Beavil AJ, Gould HJ, James LK, Sutton BJ. Mitropoulou AN, et al. Among authors: beavil aj. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8707-E8716. doi: 10.1073/pnas.1806840115. Epub 2018 Aug 27. Proc Natl Acad Sci U S A. 2018. PMID: 30150373 Free PMC article.
59 results