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The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators.
Chen J, Thrasher K, Fu L, Wang W, Aghamohammadzadeh S, Wen H, Tang L, Keeling KM, Falk Libby E, Bedwell DM, Rowe SM. Chen J, et al. Among authors: wen h. Am J Physiol Lung Cell Mol Physiol. 2023 Jun 1;324(6):L756-L770. doi: 10.1152/ajplung.00038.2023. Epub 2023 Apr 4. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37014818 Free PMC article.
Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR.
Birket SE, Davis JM, Fernandez-Petty CM, Henderson AG, Oden AM, Tang L, Wen H, Hong J, Fu L, Chambers A, Fields A, Zhao G, Tearney GJ, Sorscher EJ, Rowe SM. Birket SE, et al. Among authors: wen h. Am J Respir Crit Care Med. 2020 Nov 1;202(9):1271-1282. doi: 10.1164/rccm.202002-0369OC. Am J Respir Crit Care Med. 2020. PMID: 32584141 Free PMC article.
Role of oxygen availability in CFTR expression and function.
Guimbellot JS, Fortenberry JA, Siegal GP, Moore B, Wen H, Venglarik C, Chen YF, Oparil S, Sorscher EJ, Hong JS. Guimbellot JS, et al. Among authors: wen h. Am J Respir Cell Mol Biol. 2008 Nov;39(5):514-21. doi: 10.1165/rcmb.2007-0452OC. Epub 2008 May 12. Am J Respir Cell Mol Biol. 2008. PMID: 18474670 Free PMC article.
Micro-RNA-like effects of complete intronic sequences.
Hill AE, Hong JS, Wen H, Teng L, McPherson DT, McPherson SA, Levasseur DN, Sorscher EJ. Hill AE, et al. Among authors: wen h. Front Biosci. 2006 May 1;11:1998-2006. doi: 10.2741/1941. Front Biosci. 2006. PMID: 16368574
4,787 results