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Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists.
J Med Chem. 2023 Apr 13;66(7):4588-4602. doi: 10.1021/acs.jmedchem.2c01448. Epub 2023 Apr 3.
J Med Chem. 2023.
PMID: 37010933
Free PMC article.
Distinct Regulation of Cardiac Fibroblast Proliferation and Transdifferentiation by Classical and Novel Protein Kinase C Isoforms: Possible Implications for New Antifibrotic Therapies.
Karhu ST, Ruskoaho H, Talman V.
Karhu ST, et al.
Mol Pharmacol. 2021 Feb;99(2):104-113. doi: 10.1124/molpharm.120.000094. Epub 2020 Nov 25.
Mol Pharmacol. 2021.
PMID: 33239332
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Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.
Karhu ST, Välimäki MJ, Jumppanen M, Kinnunen SM, Pohjolainen L, Leigh RS, Auno S, Földes G, Boije Af Gennäs G, Yli-Kauhaluoma J, Ruskoaho H, Talman V.
Karhu ST, et al.
Arch Toxicol. 2018 Sep;92(9):2897-2911. doi: 10.1007/s00204-018-2257-1. Epub 2018 Jul 9.
Arch Toxicol. 2018.
PMID: 29987409
Free PMC article.
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GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes.
Karhu ST, Kinnunen SM, Tölli M, Välimäki MJ, Szabó Z, Talman V, Ruskoaho H.
Karhu ST, et al.
Arch Toxicol. 2020 Jun;94(6):2113-2130. doi: 10.1007/s00204-020-02711-8. Epub 2020 Mar 17.
Arch Toxicol. 2020.
PMID: 32185414
Free PMC article.
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Molecular Atlas of Postnatal Mouse Heart Development.
Talman V, Teppo J, Pöhö P, Movahedi P, Vaikkinen A, Karhu ST, Trošt K, Suvitaival T, Heikkonen J, Pahikkala T, Kotiaho T, Kostiainen R, Varjosalo M, Ruskoaho H.
Talman V, et al. Among authors: karhu st.
J Am Heart Assoc. 2018 Oct 16;7(20):e010378. doi: 10.1161/JAHA.118.010378.
J Am Heart Assoc. 2018.
PMID: 30371266
Free PMC article.
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Profiles of Volatile Compounds in Blackcurrant ( Ribes nigrum) Cultivars with a Special Focus on the Influence of Growth Latitude and Weather Conditions.
Marsol-Vall A, Kortesniemi M, Karhu ST, Kallio H, Yang B.
Marsol-Vall A, et al. Among authors: karhu st.
J Agric Food Chem. 2018 Jul 18;66(28):7485-7495. doi: 10.1021/acs.jafc.8b02070. Epub 2018 Jul 9.
J Agric Food Chem. 2018.
PMID: 29938497
Free PMC article.
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Triacylglycerol biosynthesis in developing Ribes nigrum and Ribes rubrum seeds from gene expression to oil composition.
Vuorinen AL, Kalpio M, Linderborg KM, Hoppula KB, Karhu ST, Yang B, Kallio HP.
Vuorinen AL, et al. Among authors: karhu st.
Food Chem. 2016 Apr 1;196:976-87. doi: 10.1016/j.foodchem.2015.10.010. Epub 2015 Oct 9.
Food Chem. 2016.
PMID: 26593580
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