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Carfentanil is a β-arrestin-biased agonist at the μ opioid receptor.
Ramos-Gonzalez N, Groom S, Sutcliffe KJ, Bancroft S, Bailey CP, Sessions RB, Henderson G, Kelly E. Ramos-Gonzalez N, et al. Among authors: sutcliffe kj. Br J Pharmacol. 2023 Sep;180(18):2341-2360. doi: 10.1111/bph.16084. Epub 2023 May 18. Br J Pharmacol. 2023. PMID: 37005796 Free PMC article.
The anomalous pharmacology of fentanyl.
Kelly E, Sutcliffe K, Cavallo D, Ramos-Gonzalez N, Alhosan N, Henderson G. Kelly E, et al. Br J Pharmacol. 2023 Apr;180(7):797-812. doi: 10.1111/bph.15573. Epub 2021 Jul 2. Br J Pharmacol. 2023. PMID: 34030211 Free article. Review.
A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.
Dekan Z, Sianati S, Yousuf A, Sutcliffe KJ, Gillis A, Mallet C, Singh P, Jin AH, Wang AM, Mohammadi SA, Stewart M, Ratnayake R, Fontaine F, Lacey E, Piggott AM, Du YP, Canals M, Sessions RB, Kelly E, Capon RJ, Alewood PF, Christie MJ. Dekan Z, et al. Among authors: sutcliffe kj. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22353-22358. doi: 10.1073/pnas.1908662116. Epub 2019 Oct 14. Proc Natl Acad Sci U S A. 2019. PMID: 31611414 Free PMC article.
Interaction With the Lipid Membrane Influences Fentanyl Pharmacology.
Sutcliffe KJ, Corey RA, Alhosan N, Cavallo D, Groom S, Santiago M, Bailey C, Charlton SJ, Sessions RB, Henderson G, Kelly E. Sutcliffe KJ, et al. Adv Drug Alcohol Res. 2022 Mar 21;2:10280. doi: 10.3389/adar.2022.10280. Adv Drug Alcohol Res. 2022. PMID: 35909438 Free PMC article.
CFTR Modulators: From Mechanism to Targeted Therapeutics.
Yeh HI, Sutcliffe KJ, Sheppard DN, Hwang TC. Yeh HI, et al. Among authors: sutcliffe kj. Handb Exp Pharmacol. 2024;283:219-247. doi: 10.1007/164_2022_597. Handb Exp Pharmacol. 2024. PMID: 35972584