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Identification of active main metabolites of anti-infective inhibitors of the macrophage infectivity potentiator protein by liquid chromatography using mass detection.
Arch Pharm (Weinheim). 2024 Apr 30:e2400032. doi: 10.1002/ardp.202400032. Online ahead of print.
Arch Pharm (Weinheim). 2024.
PMID: 38687906
Inhibition of macrophage infectivity potentiator in Burkholderia pseudomallei suppresses pro-inflammatory responses in murine macrophages.
Iwasaki J, Bzdyl NM, Lin-Sullivan DJM, Scheuplein NJ, Dueñas ME, de Jong E, Harmer NJ, Holzgrabe U, Sarkar-Tyson M.
Iwasaki J, et al. Among authors: scheuplein nj.
Front Cell Infect Microbiol. 2024 Mar 25;14:1353682. doi: 10.3389/fcimb.2024.1353682. eCollection 2024.
Front Cell Infect Microbiol. 2024.
PMID: 38590438
Free PMC article.
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Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis.
Debowski AW, Bzdyl NM, Thomas DR, Scott NE, Jenkins CH, Iwasaki J, Kibble EA, Khoo CA, Scheuplein NJ, Seibel PM, Lohr T, Metters G, Bond CS, Norville IH, Stubbs KA, Harmer NJ, Holzgrabe U, Newton HJ, Sarkar-Tyson M.
Debowski AW, et al. Among authors: scheuplein nj.
PLoS Pathog. 2023 Jul 3;19(7):e1011491. doi: 10.1371/journal.ppat.1011491. eCollection 2023 Jul.
PLoS Pathog. 2023.
PMID: 37399210
Free PMC article.
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Analysis of Structure-Activity Relationships of Novel Inhibitors of the Macrophage Infectivity Potentiator (Mip) Proteins of Neisseria meningitidis, Neisseria gonorrhoeae, and Burkholderia pseudomallei.
Scheuplein NJ, Bzdyl NM, Lohr T, Kibble EA, Hasenkopf A, Herbst C, Sarkar-Tyson M, Holzgrabe U.
Scheuplein NJ, et al.
J Med Chem. 2023 Jul 13;66(13):8876-8895. doi: 10.1021/acs.jmedchem.3c00458. Epub 2023 Jun 30.
J Med Chem. 2023.
PMID: 37389560
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Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei.
Scheuplein NJ, Lohr T, Vivoli Vega M, Ankrett D, Seufert F, Kirchner L, Harmer NJ, Holzgrabe U.
Scheuplein NJ, et al.
SLAS Discov. 2023 Jul;28(5):211-222. doi: 10.1016/j.slasd.2023.03.004. Epub 2023 Mar 29.
SLAS Discov. 2023.
PMID: 37001588
Free article.
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Targeting Protein Folding: A Novel Approach for the Treatment of Pathogenic Bacteria.
Scheuplein NJ, Bzdyl NM, Kibble EA, Lohr T, Holzgrabe U, Sarkar-Tyson M.
Scheuplein NJ, et al.
J Med Chem. 2020 Nov 25;63(22):13355-13388. doi: 10.1021/acs.jmedchem.0c00911. Epub 2020 Aug 28.
J Med Chem. 2020.
PMID: 32786507
Review.
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