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Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone.
Michaelides M, Levinstein M, De Oliveira P, Casajuana-Martin N, Quiroz C, Budinich R, Rais R, Rea W, Ventriglia E, Llopart N, Casadó-Anguera V, Moreno E, Walther D, Glatfelter G, Weinshenker D, Zarate C, Casado V, Baumann M, Pardo L, Ferre S. Michaelides M, et al. Among authors: rais r. Res Sq [Preprint]. 2023 Mar 23:rs.3.rs-2644719. doi: 10.21203/rs.3.rs-2644719/v1. Res Sq. 2023. PMID: 36993715 Free PMC article. Updated. Preprint.
Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.
Rahn KA, Watkins CC, Alt J, Rais R, Stathis M, Grishkan I, Crainiceau CM, Pomper MG, Rojas C, Pletnikov MV, Calabresi PA, Brandt J, Barker PB, Slusher BS, Kaplin AI. Rahn KA, et al. Among authors: rais r. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20101-6. doi: 10.1073/pnas.1209934109. Epub 2012 Nov 19. Proc Natl Acad Sci U S A. 2012. PMID: 23169655 Free PMC article.
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.
Šála M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hřebabecký H, Procházková E, Nešuta O, Donoghue A, Lam J, Rais R, Rojas C, Slusher BS, Nencka R. Šála M, et al. Among authors: rais r. J Med Chem. 2020 Jun 11;63(11):6028-6056. doi: 10.1021/acs.jmedchem.0c00278. Epub 2020 May 27. J Med Chem. 2020. PMID: 32298582 Free PMC article.
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Shukla K, Ferraris DV, Thomas AG, Stathis M, Duvall B, Delahanty G, Alt J, Rais R, Rojas C, Gao P, Xiang Y, Dang CV, Slusher BS, Tsukamoto T. Shukla K, et al. Among authors: rais r. J Med Chem. 2012 Dec 13;55(23):10551-63. doi: 10.1021/jm301191p. Epub 2012 Nov 30. J Med Chem. 2012. PMID: 23151085 Free PMC article.
Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.
Hollinger KR, Smith MD, Kirby LA, Prchalova E, Alt J, Rais R, Calabresi PA, Slusher BS. Hollinger KR, et al. Among authors: rais r. Neurol Neuroimmunol Neuroinflamm. 2019 Aug 29;6(6):e609. doi: 10.1212/NXI.0000000000000609. Print 2019 Nov. Neurol Neuroimmunol Neuroinflamm. 2019. PMID: 31467038 Free PMC article.
169 results