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Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone.
Michaelides M, Levinstein M, De Oliveira P, Casajuana-Martin N, Quiroz C, Budinich R, Rais R, Rea W, Ventriglia E, Llopart N, Casadó-Anguera V, Moreno E, Walther D, Glatfelter G, Weinshenker D, Zarate C, Casado V, Baumann M, Pardo L, Ferre S. Michaelides M, et al. Res Sq [Preprint]. 2023 Mar 23:rs.3.rs-2644719. doi: 10.21203/rs.3.rs-2644719/v1. Res Sq. 2023. PMID: 36993715 Free PMC article. Updated. Preprint.
Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids.
Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, Greenblatt AD, Jacobson AE, Rice KC, Casadó V, Newman AH, Winkelman JW, Michaelides M, Weintraub E, Volkow ND, Belcher AM, Ferré S. Cai NS, et al. Among authors: michaelides m. J Clin Invest. 2019 Mar 26;129(7):2730-2744. doi: 10.1172/JCI126912. J Clin Invest. 2019. PMID: 30913037 Free PMC article.
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability.
Bonaventura J, Lam S, Carlton M, Boehm MA, Gomez JL, Solís O, Sánchez-Soto M, Morris PJ, Fredriksson I, Thomas CJ, Sibley DR, Shaham Y, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Mol Psychiatry. 2021 Nov;26(11):6704-6722. doi: 10.1038/s41380-021-01093-2. Epub 2021 Apr 15. Mol Psychiatry. 2021. PMID: 33859356 Free PMC article.
Time will tell. Reply to "Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al." by Chen et al.
Bonaventura J, Lam S, Carlton M, Boehm M, Gomez JL, Solís O, Sánchez-Soto M, Morris PJ, Fredriksson I, Thomas CJ, Sibley DR, Shaham Y, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Mol Psychiatry. 2022 Apr;27(4):1863-1865. doi: 10.1038/s41380-022-01480-3. Epub 2022 Feb 22. Mol Psychiatry. 2022. PMID: 35194167 Free PMC article. No abstract available.
The show must go on. Reply to "Distinct functions of S-ketamine and R-ketamine in mediating biobehavioral processes of drug dependency: comments on Bonaventura et al" by Insop Shim.
Bonaventura J, Lam S, Carlton M, Boehm M, Gomez JL, Solís O, Sánchez-Soto M, Morris PJ, Fredriksson I, Thomas CJ, Sibley DR, Shaham Y, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Mol Psychiatry. 2023 Dec;28(12):4941-4942. doi: 10.1038/s41380-022-01666-9. Epub 2022 Jun 22. Mol Psychiatry. 2023. PMID: 35732692 No abstract available.
Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search.
Bonaventura J, Gomez JL, Carlton ML, Lam S, Sanchez-Soto M, Morris PJ, Moaddel R, Kang HJ, Zanos P, Gould TD, Thomas CJ, Sibley DR, Zarate CA Jr, Michaelides M. Bonaventura J, et al. Among authors: michaelides m. Mol Psychiatry. 2022 Oct;27(10):4144-4156. doi: 10.1038/s41380-022-01673-w. Epub 2022 Jun 29. Mol Psychiatry. 2022. PMID: 35768639 Free PMC article.
Essential role of P-glycoprotein in the mechanism of action of oliceridine.
Ventriglia E, Rizzo A, Gomez JL, Friedman J, Lam S, Solís O, Rais R, Bonaventura J, Michaelides M. Ventriglia E, et al. Among authors: michaelides m. Neuropsychopharmacology. 2023 Apr;48(5):831-842. doi: 10.1038/s41386-022-01507-x. Epub 2022 Nov 25. Neuropsychopharmacology. 2023. PMID: 36434081 Free PMC article.
In vivo photopharmacology with light-activated opioid drugs.
McClain SP, Ma X, Johnson DA, Johnson CA, Layden AE, Yung JC, Lubejko ST, Livrizzi G, Jenny He X, Zhou J, Ventriglia E, Rizzo A, Levinstein M, Gomez JL, Bonaventura J, Michaelides M, Banghart MR. McClain SP, et al. Among authors: michaelides m. bioRxiv [Preprint]. 2023 Feb 3:2023.02.02.526901. doi: 10.1101/2023.02.02.526901. bioRxiv. 2023. PMID: 36778286 Free PMC article. Updated. Preprint.
A non-canonical striatopallidal "Go" pathway that supports motor control.
Labouesse MA, Torres-Herraez A, Chohan MO, Villarin J, Greenwald J, Sun X, Zahran M, Tang A, Lam S, Veenstra-VanderWeele J, Lacefield C, Bonaventura J, Michaelides M, Chan CS, Yizhar O, Kellendonk C. Labouesse MA, et al. Among authors: michaelides m. Res Sq [Preprint]. 2023 Feb 11:rs.3.rs-2524816. doi: 10.21203/rs.3.rs-2524816/v1. Res Sq. 2023. PMID: 36798372 Free PMC article. Updated. Preprint.
668 results