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The toxicity of Aspidosperma subincanum to MCF7 cells is related to modulation of oxidative status and proinflammatory pathways.
Santos AF, Santos Mota NSR, Schiefer EM, da Cunha RS, Junkert AM, Stinghen AEM, Pontarolo R, Crisma AR, Weffort-Santos AM, Pedrosa RC, de Souza WM, Felipe KB. Santos AF, et al. Among authors: felipe kb. J Ethnopharmacol. 2021 Dec 5;281:114512. doi: 10.1016/j.jep.2021.114512. Epub 2021 Aug 9. J Ethnopharmacol. 2021. PMID: 34384848
Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation of ROS in tumor cells that inhibits proliferation and triggers apoptosis.
Günther TM, Kviecinski MR, Baron CC, Felipe KB, Farias MS, da Silva FO, Bücker NC, Pich CT, Ferreira EA, Wilhelm Filho D, Verrax J, Calderon PB, Pedrosa RC. Günther TM, et al. Among authors: felipe kb. Biochem Biophys Res Commun. 2013 Jan 18;430(3):883-8. doi: 10.1016/j.bbrc.2012.12.061. Epub 2012 Dec 19. Biochem Biophys Res Commun. 2013. PMID: 23261463 Free article.
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