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Correction: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.
Wohlwend M, Laurila PP, Goeminne LJE, de Lima TI, Daskalaki I, Li X, von Alvensleben G, Crisol B, Mangione R, Gallart-Ayala H, Lalou A, Burri O, Butler S, Morris JC, Turner N, Ivanisevic J, Auwerx J. Wohlwend M, et al. Among authors: laurila pp. Elife. 2024 May 20;13:e99846. doi: 10.7554/eLife.99846. Elife. 2024. PMID: 38767943 Free PMC article.
Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.
Wohlwend M, Laurila PP, Goeminne LJE, Lima T, Daskalaki I, Li X, von Alvensleben G, Crisol B, Mangione R, Gallart-Ayala H, Lalou A, Burri O, Butler S, Morris J, Turner N, Ivanisevic J, Auwerx J. Wohlwend M, et al. Among authors: laurila pp. Elife. 2024 Mar 20;12:RP90522. doi: 10.7554/eLife.90522. Elife. 2024. PMID: 38506902 Free PMC article.
Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging.
Lima TI, Laurila PP, Wohlwend M, Morel JD, Goeminne LJE, Li H, Romani M, Li X, Oh CM, Park D, Rodríguez-López S, Ivanisevic J, Gallart-Ayala H, Crisol B, Delort F, Batonnet-Pichon S, Silveira LR, Sankabattula Pavani Veera Venkata L, Padala AK, Jain S, Auwerx J. Lima TI, et al. Among authors: laurila pp. Sci Transl Med. 2023 May 17;15(696):eade6509. doi: 10.1126/scitranslmed.ade6509. Epub 2023 May 17. Sci Transl Med. 2023. PMID: 37196064
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia.
Laurila PP, Wohlwend M, Imamura de Lima T, Luan P, Herzig S, Zanou N, Crisol B, Bou-Sleiman M, Porcu E, Gallart-Ayala H, Handzlik MK, Wang Q, Jain S, D'Amico D, Salonen M, Metallo CM, Kutalik Z, Eichmann TO, Place N, Ivanisevic J, Lahti J, Eriksson JG, Auwerx J. Laurila PP, et al. Nat Aging. 2022 Dec;2(12):1159-1175. doi: 10.1038/s43587-022-00309-6. Epub 2022 Dec 16. Nat Aging. 2022. PMID: 37118545
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Benegiamo G, Bou Sleiman M, Wohlwend M, Rodríguez-López S, Goeminne LJE, Laurila PP, Klevjer M, Salonen MK, Lahti J, Jha P, Cogliati S, Enriquez JA, Brumpton BM, Bye A, Eriksson JG, Auwerx J. Benegiamo G, et al. Among authors: laurila pp. Nat Metab. 2022 Oct;4(10):1336-1351. doi: 10.1038/s42255-022-00655-0. Epub 2022 Oct 17. Nat Metab. 2022. PMID: 36253618 Free PMC article.
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy.
Laurila PP, Luan P, Wohlwend M, Zanou N, Crisol B, Imamura de Lima T, Goeminne LJE, Gallart-Ayala H, Shong M, Ivanisevic J, Place N, Auwerx J. Laurila PP, et al. Sci Adv. 2022 Jan 28;8(4):eabh4423. doi: 10.1126/sciadv.abh4423. Epub 2022 Jan 28. Sci Adv. 2022. PMID: 35089797 Free PMC article.
The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging.
Wohlwend M, Laurila PP, Williams K, Romani M, Lima T, Pattawaran P, Benegiamo G, Salonen M, Schneider BL, Lahti J, Eriksson JG, Barrès R, Wisløff U, Moreira JBN, Auwerx J. Wohlwend M, et al. Among authors: laurila pp. Sci Transl Med. 2021 Dec 8;13(623):eabc7367. doi: 10.1126/scitranslmed.abc7367. Epub 2021 Dec 8. Sci Transl Med. 2021. PMID: 34878822
94 results