Hurtado-Guerrero R - Search Results

1

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern.

Gonzalez-Rodriguez E, Zol-Hanlon M, Bineva-Todd G, Marchesi A, Skehel M, Mahoney KE, Roustan C, Borg A, Di Vagno L, Kjær S, Wrobel AG, Benton DJ, Nawrath P, Flitsch SL, Joshi D, González-Ramírez AM, Wilkinson KA, Wilkinson RJ, Wall EC, Hurtado-Guerrero R, Malaker SA, Schumann B. Gonzalez-Rodriguez E, et al. Among authors: hurtado guerrero r. ACS Cent Sci. 2023 Feb 16;9(3):393-404. doi: 10.1021/acscentsci.2c01349. eCollection 2023 Mar 22. ACS Cent Sci. 2023. PMID: 36968546 Free PMC article.

2

The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein.

Liu F, Xu K, Xu Z, de Las Rivas M, Wang C, Li X, Lu J, Zhou Y, Delso I, Merino P, Hurtado-Guerrero R, Zhang Y, Wu F. Liu F, et al. J Biol Chem. 2017 Dec 29;292(52):21304-21319. doi: 10.1074/jbc.M117.814202. Epub 2017 Oct 23. J Biol Chem. 2017. PMID: 29061849 Free PMC article.

3

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase.

García-García A, Ceballos-Laita L, Serna S, Artschwager R, Reichardt NC, Corzana F, Hurtado-Guerrero R. García-García A, et al. Nat Commun. 2020 Feb 20;11(1):973. doi: 10.1038/s41467-020-14794-z. Nat Commun. 2020. PMID: 32080177 Free PMC article.

4

Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition.

Bermejo IA, Usabiaga I, Compañón I, Castro-López J, Insausti A, Fernández JA, Avenoza A, Busto JH, Jiménez-Barbero J, Asensio JL, Peregrina JM, Jiménez-Osés G, Hurtado-Guerrero R, Cocinero EJ, Corzana F. Bermejo IA, et al. J Am Chem Soc. 2018 Aug 8;140(31):9952-9960. doi: 10.1021/jacs.8b04801. Epub 2018 Jul 30. J Am Chem Soc. 2018. PMID: 30004703

5

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor.

Raimi OG, Hurtado-Guerrero R, Borodkin V, Ferenbach A, Urbaniak MD, Ferguson MAJ, van Aalten DMF. Raimi OG, et al. RSC Chem Biol. 2020 Mar 24;1(1):13-25. doi: 10.1039/c9cb00017h. eCollection 2020 Apr 16. RSC Chem Biol. 2020. PMID: 34458745 Free PMC article.

6

Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives.

Rubio-Ruiz B, Figuerola-Conchas A, Ramos-Torrecillas J, Capitán-Cañadas F, Ríos-Marco P, Carrasco MP, Gallo MÁ, Espinosa A, Marco C, Ruiz C, Entrena A, Hurtado-Guerrero R, Conejo-García A. Rubio-Ruiz B, et al. J Med Chem. 2014 Jan 23;57(2):507-15. doi: 10.1021/jm401665x. Epub 2014 Jan 14. J Med Chem. 2014. PMID: 24387243

7

Rational Design of Glycomimetic Compounds Targeting the Saccharomyces cerevisiae Transglycosylase Gas2.

Delso I, Valero-González J, Marca E, Tejero T, Hurtado-Guerrero R, Merino P. Delso I, et al. Chem Biol Drug Des. 2016 Feb;87(2):163-70. doi: 10.1111/cbdd.12650. Epub 2015 Sep 21. Chem Biol Drug Des. 2016. PMID: 26280762

8

Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death.

Serrán-Aguilera L, Denton H, Rubio-Ruiz B, López-Gutiérrez B, Entrena A, Izquierdo L, Smith TK, Conejo-García A, Hurtado-Guerrero R. Serrán-Aguilera L, et al. Sci Rep. 2016 Sep 12;6:33189. doi: 10.1038/srep33189. Sci Rep. 2016. PMID: 27616047 Free PMC article.

9

A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations.

Raich L, Borodkin V, Fang W, Castro-López J, van Aalten DM, Hurtado-Guerrero R, Rovira C. Raich L, et al. J Am Chem Soc. 2016 Mar 16;138(10):3325-32. doi: 10.1021/jacs.5b10092. Epub 2016 Mar 1. J Am Chem Soc. 2016. PMID: 26859322

10

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target.

Fang W, Du T, Raimi OG, Hurtado-Guerrero R, Urbaniak MD, Ibrahim AF, Ferguson MA, Jin C, van Aalten DM. Fang W, et al. Mol Microbiol. 2013 Aug;89(3):479-93. doi: 10.1111/mmi.12290. Epub 2013 Jul 5. Mol Microbiol. 2013. PMID: 23750903 Free PMC article.

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