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Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease.
Minowa K, Rodriguez-Agudo D, Suzuki M, Muto Y, Hirai S, Wang Y, Su L, Zhou H, Chen Q, Lesnefsky EJ, Mitamura K, Ikegawa S, Takei H, Nittono H, Fuchs M, Pandak WM, Kakiyama G. Minowa K, et al. Among authors: ikegawa s. J Lipid Res. 2023 May;64(5):100363. doi: 10.1016/j.jlr.2023.100363. Epub 2023 Mar 24. J Lipid Res. 2023. PMID: 36966904 Free PMC article.
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model.
Kakiyama G, Minowa K, Rodriguez-Agudo D, Martin R, Takei H, Mitamura K, Ikegawa S, Suzuki M, Nittono H, Fuchs M, Heuman DM, Zhou H, Pandak WM. Kakiyama G, et al. Among authors: ikegawa s. Am J Physiol Gastrointest Liver Physiol. 2022 Nov 1;323(5):G488-G500. doi: 10.1152/ajpgi.00179.2022. Epub 2022 Oct 4. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 36193897 Free PMC article.
Oxysterols are substrates for cholesterol sulfotransferase.
Fuda H, Javitt NB, Mitamura K, Ikegawa S, Strott CA. Fuda H, et al. Among authors: ikegawa s. J Lipid Res. 2007 Jun;48(6):1343-52. doi: 10.1194/jlr.M700018-JLR200. Epub 2007 Mar 8. J Lipid Res. 2007. PMID: 17347498 Free article.
Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids.
Muto A, Takei H, Unno A, Murai T, Kurosawa T, Ogawa S, Iida T, Ikegawa S, Mori J, Ohtake A, Hoshina T, Mizuochi T, Kimura A, Hofmann AF, Hagey LR, Nittono H. Muto A, et al. Among authors: ikegawa s. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jul 1;900:24-31. doi: 10.1016/j.jchromb.2012.05.023. Epub 2012 May 24. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22695323
624 results