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Novel gold(I) complexes induce apoptosis in leukemia cells via the ROS-induced mitochondrial pathway with an upregulation of Harakiri and overcome multi drug resistances in leukemia and lymphoma cells and sensitize drug resistant tumor cells to apoptosis in vitro.
Ahrweiler-Sawaryn MC, Biswas A, Frias C, Frias J, Wilke NL, Wilke N, Berkessel A, Prokop A. Ahrweiler-Sawaryn MC, et al. Among authors: wilke nl. Biomed Pharmacother. 2023 May;161:114507. doi: 10.1016/j.biopha.2023.114507. Epub 2023 Mar 21. Biomed Pharmacother. 2023. PMID: 36958194 Free article.
Gold(I) Bis(1,2,3-triazol-5-ylidene) Complexes as Promising Selective Anticancer Compounds.
Schlagintweit JF, Jakob CHG, Wilke NL, Ahrweiler M, Frias C, Frias J, König M, Esslinger EHJ, Marques F, Machado JF, Reich RM, Morais TS, Correia JDG, Prokop A, Kühn FE. Schlagintweit JF, et al. Among authors: wilke nl. J Med Chem. 2021 Nov 11;64(21):15747-15757. doi: 10.1021/acs.jmedchem.1c01021. Epub 2021 Oct 20. J Med Chem. 2021. PMID: 34670090
B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner.
Stein A, Hilken Née Thomopoulou P, Frias C, Hopff SM, Varela P, Wilke N, Mariappan A, Neudörfl JM, Fedorov AY, Gopalakrishnan J, Gigant B, Prokop A, Schmalz HG. Stein A, et al. ACS Omega. 2022 Jan 11;7(3):2591-2603. doi: 10.1021/acsomega.1c04659. eCollection 2022 Jan 25. ACS Omega. 2022. PMID: 35097257 Free PMC article.