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Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses.
Jossi SE, Arcuri M, Alshayea A, Persaud RR, Marcial-Juárez E, Palmieri E, Di Benedetto R, Pérez-Toledo M, Pillaye J, Channell WM, Schager AE, Lamerton RE, Cook CN, Goodall M, Haneda T, Bäumler AJ, Jackson-Jones LH, Toellner KM, MacLennan CA, Henderson IR, Micoli F, Cunningham AF. Jossi SE, et al. Among authors: alshayea a. Front Immunol. 2023 Mar 23;14:1139329. doi: 10.3389/fimmu.2023.1139329. eCollection 2023. Front Immunol. 2023. PMID: 37033932 Free PMC article.
Salmonella infection induces the reorganization of follicular dendritic cell networks concomitant with the failure to generate germinal centers.
Marcial-Juárez E, Pérez-Toledo M, Nayar S, Pipi E, Alshayea A, Persaud R, Jossi SE, Lamerton R, Barone F, Henderson IR, Cunningham AF. Marcial-Juárez E, et al. Among authors: alshayea a. iScience. 2023 Mar 2;26(4):106310. doi: 10.1016/j.isci.2023.106310. eCollection 2023 Apr 21. iScience. 2023. PMID: 36950118 Free PMC article.
Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface.
Domínguez-Medina CC, Pérez-Toledo M, Schager AE, Marshall JL, Cook CN, Bobat S, Hwang H, Chun BJ, Logan E, Bryant JA, Channell WM, Morris FC, Jossi SE, Alshayea A, Rossiter AE, Barrow PA, Horsnell WG, MacLennan CA, Henderson IR, Lakey JH, Gumbart JC, López-Macías C, Bavro VN, Cunningham AF. Domínguez-Medina CC, et al. Among authors: alshayea a. Nat Commun. 2020 Feb 12;11(1):851. doi: 10.1038/s41467-020-14655-9. Nat Commun. 2020. PMID: 32051408 Free PMC article.