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A molecular glue approach to control the half-life of CRISPR-based technologies.
Sreekanth V, Jan M, Zhao KT, Lim D, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann M, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A. Sreekanth V, et al. Among authors: sherwood ri. bioRxiv [Preprint]. 2023 Mar 20:2023.03.12.531757. doi: 10.1101/2023.03.12.531757. bioRxiv. 2023. PMID: 36945568 Free PMC article. Preprint.
Predictable and precise template-free CRISPR editing of pathogenic variants.
Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI. Shen MW, et al. Among authors: sherwood ri. Nature. 2018 Nov;563(7733):646-651. doi: 10.1038/s41586-018-0686-x. Epub 2018 Nov 7. Nature. 2018. PMID: 30405244 Free PMC article.
Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics.
Akinci E, Cha M, Lin L, Yeo G, Hamilton MC, Donahue CJ, Bermudez-Cabrera HC, Zanetti LC, Chen M, Barkal SA, Khowpinitchai B, Chu N, Velimirovic M, Jodhani R, Fife JD, Sovrovic M, Cole PA, Davey RA, Cassa CA, Sherwood RI. Akinci E, et al. Among authors: sherwood ri. bioRxiv [Preprint]. 2020 Aug 28:2020.08.27.270819. doi: 10.1101/2020.08.27.270819. bioRxiv. 2020. PMID: 32869031 Free PMC article. Preprint.
Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes.
Sreekanth V, Zhou Q, Kokkonda P, Bermudez-Cabrera HC, Lim D, Law BK, Holmes BR, Chaudhary SK, Pergu R, Leger BS, Walker JA, Gifford DK, Sherwood RI, Choudhary A. Sreekanth V, et al. Among authors: sherwood ri. ACS Cent Sci. 2020 Dec 23;6(12):2228-2237. doi: 10.1021/acscentsci.0c00129. Epub 2020 Nov 18. ACS Cent Sci. 2020. PMID: 33376784 Free PMC article.
Peptide fusion improves prime editing efficiency.
Velimirovic M, Zanetti LC, Shen MW, Fife JD, Lin L, Cha M, Akinci E, Barnum D, Yu T, Sherwood RI. Velimirovic M, et al. Among authors: sherwood ri. Nat Commun. 2022 Jun 18;13(1):3512. doi: 10.1038/s41467-022-31270-y. Nat Commun. 2022. PMID: 35717416 Free PMC article.
Systematic elucidation of genetic mechanisms underlying cholesterol uptake.
Hamilton MC, Fife JD, Akinci E, Yu T, Khowpinitchai B, Cha M, Barkal S, Thi TT, Yeo GHT, Ramos Barroso JP, Jake Francoeur M, Velimirovic M, Gifford DK, Lettre G, Yu H, Cassa CA, Sherwood RI. Hamilton MC, et al. Among authors: sherwood ri. bioRxiv [Preprint]. 2023 Jan 10:2023.01.09.500804. doi: 10.1101/2023.01.09.500804. bioRxiv. 2023. PMID: 36711952 Free PMC article. Updated. Preprint.
53 results