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Page 1
An internal thioester in a pathogen surface protein mediates covalent host binding.
Walden M, Edwards JM, Dziewulska AM, Bergmann R, Saalbach G, Kan SY, Miller OK, Weckener M, Jackson RJ, Shirran SL, Botting CH, Florence GJ, Rohde M, Banfield MJ, Schwarz-Linek U. Walden M, et al. Among authors: weckener m. Elife. 2015 Jun 2;4:e06638. doi: 10.7554/eLife.06638. Elife. 2015. PMID: 26032562 Free PMC article.
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Huo J, Le Bas A, Ruza RR, Duyvesteyn HME, Mikolajek H, Malinauskas T, Tan TK, Rijal P, Dumoux M, Ward PN, Ren J, Zhou D, Harrison PJ, Weckener M, Clare DK, Vogirala VK, Radecke J, Moynié L, Zhao Y, Gilbert-Jaramillo J, Knight ML, Tree JA, Buttigieg KR, Coombes N, Elmore MJ, Carroll MW, Carrique L, Shah PNM, James W, Townsend AR, Stuart DI, Owens RJ, Naismith JH. Huo J, et al. Among authors: weckener m. Nat Struct Mol Biol. 2020 Sep;27(9):846-854. doi: 10.1038/s41594-020-0469-6. Epub 2020 Jul 13. Nat Struct Mol Biol. 2020. PMID: 32661423
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Huo J, Le Bas A, Ruza RR, Duyvesteyn HME, Mikolajek H, Malinauskas T, Tan TK, Rijal P, Dumoux M, Ward PN, Ren J, Zhou D, Harrison PJ, Weckener M, Clare DK, Vogirala VK, Radecke J, Moynié L, Zhao Y, Gilbert-Jaramillo J, Knight ML, Tree JA, Buttigieg KR, Coombes N, Elmore MJ, Carroll MW, Carrique L, Shah PNM, James W, Townsend AR, Stuart DI, Owens RJ, Naismith JH. Huo J, et al. Among authors: weckener m. Nat Struct Mol Biol. 2020 Nov;27(11):1094. doi: 10.1038/s41594-020-00527-9. Nat Struct Mol Biol. 2020. PMID: 33060850 Free PMC article.
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Uchański T, Masiulis S, Fischer B, Kalichuk V, López-Sánchez U, Zarkadas E, Weckener M, Sente A, Ward P, Wohlkönig A, Zögg T, Remaut H, Naismith JH, Nury H, Vranken W, Aricescu AR, Pardon E, Steyaert J. Uchański T, et al. Among authors: weckener m. Nat Methods. 2021 Jan;18(1):60-68. doi: 10.1038/s41592-020-01001-6. Epub 2021 Jan 6. Nat Methods. 2021. PMID: 33408403 Free PMC article.
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Huo J, Bas AL, Ruza RR, Duyvesteyn HME, Mikolajek H, Malinauskas T, Tan TK, Rijal P, Dumoux M, Ward PN, Ren J, Zhou D, Harrison PJ, Weckener M, Clare DK, Vogirala VK, Radecke J, Moynié L, Zhao Y, Gilbert-Jaramillo J, Knight ML, Tree JA, Buttigieg KR, Coombes N, Elmore MJ, Carroll MW, Carrique L, Shah PNM, James W, Townsend AR, Stuart DI, Owens RJ, Naismith JH. Huo J, et al. Among authors: weckener m. Nat Struct Mol Biol. 2021 Mar;28(3):326. doi: 10.1038/s41594-021-00566-w. Nat Struct Mol Biol. 2021. PMID: 33536566 Free PMC article. No abstract available.
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Huo J, Mikolajek H, Le Bas A, Clark JJ, Sharma P, Kipar A, Dormon J, Norman C, Weckener M, Clare DK, Harrison PJ, Tree JA, Buttigieg KR, Salguero FJ, Watson R, Knott D, Carnell O, Ngabo D, Elmore MJ, Fotheringham S, Harding A, Moynié L, Ward PN, Dumoux M, Prince T, Hall Y, Hiscox JA, Owen A, James W, Carroll MW, Stewart JP, Naismith JH, Owens RJ. Huo J, et al. Among authors: weckener m. Nat Commun. 2021 Sep 22;12(1):5469. doi: 10.1038/s41467-021-25480-z. Nat Commun. 2021. PMID: 34552091 Free PMC article.
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Mikolajek H, Weckener M, Brotzakis ZF, Huo J, Dalietou EV, Le Bas A, Sormanni P, Harrison PJ, Ward PN, Truong S, Moynie L, Clare DK, Dumoux M, Dormon J, Norman C, Hussain N, Vogirala V, Owens RJ, Vendruscolo M, Naismith JH. Mikolajek H, et al. Among authors: weckener m. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2205412119. doi: 10.1073/pnas.2205412119. Epub 2022 Jul 15. Proc Natl Acad Sci U S A. 2022. PMID: 35858383 Free PMC article.
CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin.
Pasqualetto G, Mack A, Lewis E, Cooper R, Holland A, Borucu U, Mantell J, Davies T, Weckener M, Clare D, Green T, Kille P, Muhlhozl A, Young MT. Pasqualetto G, et al. Among authors: weckener m. PLoS One. 2023 Jun 22;18(6):e0287294. doi: 10.1371/journal.pone.0287294. eCollection 2023. PLoS One. 2023. PMID: 37347755 Free PMC article.
12 results