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Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire.
Millar DG, Yang SYC, Sayad A, Zhao Q, Nguyen LT, Warner K, Sangster AG, Nakatsugawa M, Murata K, Wang BX, Shaw P, Clarke B, Bernardini MQ, Pugh T, Thibault P, Hirano N, Perreault C, Ohashi PS. Millar DG, et al. Among authors: sayad a. Cancer Immunol Immunother. 2023 Jul;72(7):2375-2392. doi: 10.1007/s00262-023-03413-7. Epub 2023 Mar 21. Cancer Immunol Immunother. 2023. PMID: 36943460 Free PMC article.
Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer.
MacGregor HL, Garcia-Batres C, Sayad A, Elia A, Berman HK, Toker A, Katz SR, Shaw PA, Clarke BA, Crome SQ, Robert-Tissot C, Bernardini MQ, Nguyen LT, Ohashi PS. MacGregor HL, et al. Among authors: sayad a. Oncoimmunology. 2019 Sep 30;8(12):e1665460. doi: 10.1080/2162402X.2019.1665460. eCollection 2019. Oncoimmunology. 2019. PMID: 31741762 Free PMC article.
High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation.
MacGregor HL, Sayad A, Elia A, Wang BX, Katz SR, Shaw PA, Clarke BA, Crome SQ, Robert-Tissot C, Bernardini MQ, Nguyen LT, Ohashi PS. MacGregor HL, et al. Among authors: sayad a. J Immunother Cancer. 2019 Dec 31;7(1):357. doi: 10.1186/s40425-019-0816-5. J Immunother Cancer. 2019. PMID: 31892360 Free PMC article.
IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function.
St Paul M, Saibil SD, Lien SC, Han S, Sayad A, Mulder DT, Garcia-Batres CR, Elford AR, Israni-Winger K, Robert-Tissot C, Zon M, Katz SR, Shaw PA, Clarke BA, Bernardini MQ, Nguyen LT, Haibe-Kains B, Pugh TJ, Ohashi PS. St Paul M, et al. Among authors: sayad a. Cancer Immunol Res. 2020 Mar;8(3):321-333. doi: 10.1158/2326-6066.CIR-19-0521. Epub 2020 Jan 21. Cancer Immunol Res. 2020. PMID: 31964625
Computational modeling of ovarian cancer dynamics suggests optimal strategies for therapy and screening.
Gu S, Lheureux S, Sayad A, Cybulska P, Hogen L, Vyarvelska I, Tu D, Parulekar WR, Nankivell M, Kehoe S, Chi DS, Levine DA, Bernardini MQ, Rosen B, Oza A, Brown M, Neel BG. Gu S, et al. Among authors: sayad a. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2026663118. doi: 10.1073/pnas.2026663118. Proc Natl Acad Sci U S A. 2021. PMID: 34161278 Free PMC article.
Coenzyme A fuels T cell anti-tumor immunity.
St Paul M, Saibil SD, Han S, Israni-Winger K, Lien SC, Laister RC, Sayad A, Penny S, Amaria RN, Haydu LE, Garcia-Batres CR, Kates M, Mulder DT, Robert-Tissot C, Gold MJ, Tran CW, Elford AR, Nguyen LT, Pugh TJ, Pinto DM, Wargo JA, Ohashi PS. St Paul M, et al. Among authors: sayad a. Cell Metab. 2021 Dec 7;33(12):2415-2427.e6. doi: 10.1016/j.cmet.2021.11.010. Cell Metab. 2021. PMID: 34879240 Free article.
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer.
Kondratyev M, Pesic A, Ketela T, Stickle N, Beswick C, Shalev Z, Marastoni S, Samadian S, Dvorkin-Gheva A, Sayad A, Bashkurov M, Boasquevisque P, Datti A, Pugh TJ, Virtanen C, Moffat J, Grénman RA, Koritzinsky M, Wouters BG. Kondratyev M, et al. Among authors: sayad a. Commun Biol. 2023 May 18;6(1):538. doi: 10.1038/s42003-023-04828-9. Commun Biol. 2023. PMID: 37202533 Free PMC article.
Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy.
St Paul M, Saibil SD, Kates M, Han S, Lien SC, Laister RC, Hezaveh K, Kloetgen A, Penny S, Guo T, Garcia-Batres C, Smith LK, Chung DC, Elford AR, Sayad A, Pinto D, Mak TW, Hirano N, McGaha T, Ohashi PS. St Paul M, et al. Among authors: sayad a. Cell Rep Med. 2024 Mar 19;5(3):101465. doi: 10.1016/j.xcrm.2024.101465. Epub 2024 Mar 8. Cell Rep Med. 2024. PMID: 38460518 Free PMC article.
194 results