O'Keefe BR - Search Results

1

National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks.

Evans JR, Akee RK, Chanana S, McConachie GD, Thornburg CC, Grkovic T, O'Keefe BR. Evans JR, et al. ACS Omega. 2023 Mar 1;8(10):9250-9256. doi: 10.1021/acsomega.2c07416. eCollection 2023 Mar 14. ACS Omega. 2023. PMID: 36936303 Free PMC article.

2

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.

Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR. Wilson BA, et al. J Biomol Screen. 2016 Mar;21(3):277-89. doi: 10.1177/1087057115615518. Epub 2015 Nov 4. J Biomol Screen. 2016. PMID: 26538432 Free PMC article.

3

Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1).

Bermingham A, Price E, Marchand C, Chergui A, Naumova A, Whitson EL, Krumpe LRH, Goncharova EI, Evans JR, McKee TC, Henrich CJ, Pommier Y, O'Keefe BR. Bermingham A, et al. SLAS Discov. 2017 Oct;22(9):1093-1105. doi: 10.1177/2472555217717200. Epub 2017 Jul 11. SLAS Discov. 2017. PMID: 28697309 Free PMC article.

4

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR. Thornburg CC, et al. ACS Chem Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13. ACS Chem Biol. 2018. PMID: 29812901 Free PMC article.

5

Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

Grkovic T, Evans JR, Akee RK, Guo L, Davis M, Jato J, Grothaus PG, Ahalt-Gottholm M, Hollingshead M, Collins JM, Newman DJ, O'Keefe BR. Grkovic T, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):134-137. doi: 10.1016/j.bmcl.2018.12.019. Epub 2018 Dec 10. Bioorg Med Chem Lett. 2019. PMID: 30553734 Free PMC article.

6

Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines.

Cai S, Risinger AL, Petersen CL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Cai S, et al. J Nat Prod. 2019 Apr 26;82(4):928-936. doi: 10.1021/acs.jnatprod.8b01015. Epub 2019 Mar 4. J Nat Prod. 2019. PMID: 30830773 Free PMC article.

7

The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species.

He M, Grkovic T, Evans JR, Thornburg CC, Akee RK, Thompson JR, Whitt JA, Harris MJ, Loyal JA, Britt JR, Jia L, White JD, Newman DJ, O'Keefe BR. He M, et al. Fitoterapia. 2019 Sep;137:104285. doi: 10.1016/j.fitote.2019.104285. Epub 2019 Aug 3. Fitoterapia. 2019. PMID: 31386897 Free PMC article.

8

Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris.

Kil YS, Risinger AL, Petersen CL, Liang H, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Kil YS, et al. J Nat Prod. 2020 Mar 27;83(3):584-592. doi: 10.1021/acs.jnatprod.9b00896. Epub 2020 Feb 27. J Nat Prod. 2020. PMID: 32105068 Free PMC article.

9

Creating and screening natural product libraries.

Wilson BAP, Thornburg CC, Henrich CJ, Grkovic T, O'Keefe BR. Wilson BAP, et al. Nat Prod Rep. 2020 Jul 1;37(7):893-918. doi: 10.1039/c9np00068b. Epub 2020 Mar 18. Nat Prod Rep. 2020. PMID: 32186299 Free PMC article. Review.

10

National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library.

Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Evans JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR. Grkovic T, et al. ACS Chem Biol. 2020 Apr 17;15(4):1104-1114. doi: 10.1021/acschembio.0c00139. Epub 2020 Apr 7. ACS Chem Biol. 2020. PMID: 32223208 Free PMC article.

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